4-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT(2A) receptor antagonists

Maria J. Mokrosz, Beata Duszyńska, Aleksandra Kłodzińska, Anna Dereń-Wesołek, Ewa Chojnacka-Wójcik, Timothy C. Baranowski, Ibrahim M. Abdou, Naomi P. Redmore, Lucjan Strekowski

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The title pyrimidines 7-12 are potent 5-HT(2A) receptor ligands with fairly strong behavioral antagonistic activity. A comparison of the structural and binding properties within the entire group of these and other pyrimidines demonstrates two different modes of the bioactive complex formation.

Original languageEnglish
Pages (from-to)1635-1638
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number13
Publication statusPublished - Jul 8 1997
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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