4-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT(2A) receptor antagonists

Maria J. Mokrosz; Beata Duszyńska; Aleksandra Kłodzińska; Anna Dereń-Wesołek; Ewa Chojnacka-Wójcik; Timothy C. Baranowski; Ibrahim M. Abdou; Naomi P. Redmore; Lucjan Strekowski

doi:10.1016/S0960-894X(97)00291-6

4-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT(2A) receptor antagonists

Maria J. Mokrosz
, Beata Duszyńska
, Aleksandra Kłodzińska
, Anna Dereń-Wesołek
, Ewa Chojnacka-Wójcik
, Timothy C. Baranowski
, Ibrahim M. Abdou
, Naomi P. Redmore
, Lucjan Strekowski

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The title pyrimidines 7-12 are potent 5-HT(2A) receptor ligands with fairly strong behavioral antagonistic activity. A comparison of the structural and binding properties within the entire group of these and other pyrimidines demonstrates two different modes of the bioactive complex formation.

Original language	English
Pages (from-to)	1635-1638
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	13
DOIs	https://doi.org/10.1016/S0960-894X(97)00291-6
Publication status	Published - Jul 8 1997
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(97)00291-6

Cite this

@article{ff4bec8e7c5c4607b53b7926dcef0d4b,

title = "4-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT(2A) receptor antagonists",

abstract = "The title pyrimidines 7-12 are potent 5-HT(2A) receptor ligands with fairly strong behavioral antagonistic activity. A comparison of the structural and binding properties within the entire group of these and other pyrimidines demonstrates two different modes of the bioactive complex formation.",

author = "Mokrosz, \{Maria J.\} and Beata Duszy{\'n}ska and Aleksandra K{\l}odzi{\'n}ska and Anna Dere{\'n}-Weso{\l}ek and Ewa Chojnacka-W{\'o}jcik and Baranowski, \{Timothy C.\} and Abdou, \{Ibrahim M.\} and Redmore, \{Naomi P.\} and Lucjan Strekowski",

note = "Funding Information: Acknowledgment. T.C. Baranowski is a recipient of the fellowship of Solvay Pharmaceuticals, Inc., Marietta, Georgia, USA. I.M. Abdou is a Channel student of Tanta University, Tanta, Egypt.",

year = "1997",

month = jul,

day = "8",

doi = "10.1016/S0960-894X(97)00291-6",

language = "English",

volume = "7",

pages = "1635--1638",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "13",

}

TY - JOUR

T1 - 4-(3-furyl)-2-(4-methylpiperazino)pyrimidines

T2 - Potent 5-HT(2A) receptor antagonists

AU - Mokrosz, Maria J.

AU - Duszyńska, Beata

AU - Kłodzińska, Aleksandra

AU - Dereń-Wesołek, Anna

AU - Chojnacka-Wójcik, Ewa

AU - Baranowski, Timothy C.

AU - Abdou, Ibrahim M.

AU - Redmore, Naomi P.

AU - Strekowski, Lucjan

N1 - Funding Information: Acknowledgment. T.C. Baranowski is a recipient of the fellowship of Solvay Pharmaceuticals, Inc., Marietta, Georgia, USA. I.M. Abdou is a Channel student of Tanta University, Tanta, Egypt.

PY - 1997/7/8

Y1 - 1997/7/8

N2 - The title pyrimidines 7-12 are potent 5-HT(2A) receptor ligands with fairly strong behavioral antagonistic activity. A comparison of the structural and binding properties within the entire group of these and other pyrimidines demonstrates two different modes of the bioactive complex formation.

AB - The title pyrimidines 7-12 are potent 5-HT(2A) receptor ligands with fairly strong behavioral antagonistic activity. A comparison of the structural and binding properties within the entire group of these and other pyrimidines demonstrates two different modes of the bioactive complex formation.

UR - https://www.scopus.com/pages/publications/0343554070

UR - https://www.scopus.com/pages/publications/0343554070#tab=citedBy

U2 - 10.1016/S0960-894X(97)00291-6

DO - 10.1016/S0960-894X(97)00291-6

M3 - Article

AN - SCOPUS:0343554070

SN - 0960-894X

VL - 7

SP - 1635

EP - 1638

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

ER -

4-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT(2A) receptor antagonists

Abstract

ASJC Scopus subject areas

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