TY - JOUR
T1 - 5-Alpha reductase inhibitors in androgenetic alopecia
T2 - Shifting paradigms, current concepts, comparative efficacy, and safety
AU - Dhurat, Rachita
AU - Sharma, Aseem
AU - Rudnicka, Lidia
AU - Kroumpouzos, George
AU - Kassir, Martin
AU - Galadari, Hassan
AU - Wollina, Uwe
AU - Lotti, Torello
AU - Golubovic, Masa
AU - Binic, Iva
AU - Grabbe, Stephan
AU - Goldust, Mohamad
N1 - Publisher Copyright:
© 2020 Wiley Periodicals LLC.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Androgenetic alopecia (AGA) is a multifactorial disease that carries a significant psychological burden with it. Dihydrotestosterone, the main pathogenic androgen in AGA, is produced by conversion of testosterone, which is catalyzed by the 5-alpha reductase (5-AR) isoenzyme family. Finasteride and dutasteride are inhibitors of these enzymes. Finasteride, which is a single receptor 5-alpha reductase inhibitor (5-ARI), acts by blocking dihydrotestosterone (DHT). Dutasteride, a dual receptor DHT blocker, has a higher potency than its predecessor, finasteride. This review corroborates the evidence of superiority of dutasteride over finasteride, and its comparable safety profile concerning fertility, teratogenicity, neurotoxicity, and hepatotoxicity.
AB - Androgenetic alopecia (AGA) is a multifactorial disease that carries a significant psychological burden with it. Dihydrotestosterone, the main pathogenic androgen in AGA, is produced by conversion of testosterone, which is catalyzed by the 5-alpha reductase (5-AR) isoenzyme family. Finasteride and dutasteride are inhibitors of these enzymes. Finasteride, which is a single receptor 5-alpha reductase inhibitor (5-ARI), acts by blocking dihydrotestosterone (DHT). Dutasteride, a dual receptor DHT blocker, has a higher potency than its predecessor, finasteride. This review corroborates the evidence of superiority of dutasteride over finasteride, and its comparable safety profile concerning fertility, teratogenicity, neurotoxicity, and hepatotoxicity.
KW - 5-alpha reductase inhibitors
KW - androgenetic alopecia
KW - dutasteride
KW - finasteride
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U2 - 10.1111/dth.13379
DO - 10.1111/dth.13379
M3 - Review article
C2 - 32279398
AN - SCOPUS:85083803337
SN - 1396-0296
VL - 33
JO - Dermatologic Therapy
JF - Dermatologic Therapy
IS - 3
M1 - e13379
ER -