5-HT2 receptors-mediated modulation of voltage-gated K + channels and neurophysiopathological correlates

Maria Cristina D'Adamo, Ilenio Servettini, Luca Guglielmi, Vincenzo Di Matteo, Roberto Di Maio, Giuseppe Di Giovanni, Mauro Pessia

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


The activity of voltage-gated K+ channels (Kv) can be dynamically modulated by several events, including neurotransmitter stimulated biochemical cascades mediated by G protein-coupled receptors such as 5-HT 2 receptors (5-HT2Rs). Activation of 5-HT2A/CR inhibits the Shaker-like K+ channels Kv1.1 and Kv1.2, and this modulation involves the dual coordination of both RPTPα and distinct tyrosine kinases coupled to this receptor; 5-HT2Rs-mediated modulation of Kv channels controls glutamate release onto prefrontal cortex neurons that might play critical roles in neurophysiological, neurological, and psychiatric conditions. Noticeably, hallucinogens modulate Kv channel activity, acting at 5-HT2R. Hence, comprehensive knowledge of 5-HT2R signaling through modulation of distinct K+ channels is a pivotal step in the direction that will enable scientists to discover novel 5-HT functions and dysfunctions in the brain and to identify original therapeutic targets.

Original languageEnglish
Pages (from-to)453-462
Number of pages10
JournalExperimental Brain Research
Issue number4
Publication statusPublished - Oct 2013
Externally publishedYes


  • 5-HT
  • 5-HT
  • Cortical pyramidal neuron
  • Kinase
  • Kv1.1
  • Kv1.2
  • Phosphatase
  • RPTPα
  • Serotonin receptor
  • Tyrosine phosphorylation

ASJC Scopus subject areas

  • General Neuroscience


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