A 1.4-Mb interval RH map of horse chromosome 17 provides detailed comparison with human and mouse homologues

Eun Joon Lee, Terje Raudsepp, Srinivas R. Kata, David Adelson, James E. Womack, Loren C. Skow, Bhanu P. Chowdhary

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Comparative genomics has served as a backbone for the rapid development of gene maps in domesticated animals. The integration of this approach with radiation hybrid (RH) analysis provides one of the most direct ways to obtain physically ordered comparative maps across evolutionarily diverged species. We herein report the development of a detailed RH and comparative map for horse chromosome 17 (ECA17). With markers distributed at an average interval of every 1.4 Mb, the map is currently the most informative among the equine chromosomes. It comprises 75 markers (56 genes and 19 microsatellites), of which 50 gene specific and 5 microsatellite markers were generated in this study and typed to our 5000-rad horse × hamster whole genome RH panel. The markers are dispersed over six RH linkage groups and span 825 cR5000. The map is among the most comprehensive whole chromosome comparative maps currently available for domesticated animals. It finely aligns ECA17 to human and mouse homologues (HSA13 and MMU1, 3, 5, 8, and 14, respectively) and homologues in other domesticated animals. Comparisons provide insight into their relative organization and help to identify evolutionarily conserved segments. The new ECA17 map will serve as a template for the development of clusters of BAC contigs in regions containing genes of interest. Sequencing of these regions will help to initiate studies aimed at understanding the molecular mechanisms for various diseases and inherited disorders in horse as well as human.

Original languageEnglish
Pages (from-to)203-215
Number of pages13
Issue number2
Publication statusPublished - Feb 2004
Externally publishedYes


  • Comparative map
  • ECA17
  • FISH
  • Gene mapping
  • Horse
  • RH map

ASJC Scopus subject areas

  • Genetics


Dive into the research topics of 'A 1.4-Mb interval RH map of horse chromosome 17 provides detailed comparison with human and mouse homologues'. Together they form a unique fingerprint.

Cite this