TY - GEN
T1 - A bio-analytical system for rapid cellular electrophysiological assays
AU - Fatoyinbo, Henry O.
AU - Gould, David H.
AU - Labeed, Fatima H.
PY - 2010
Y1 - 2010
N2 - In this paper, the use of non-uniform ac electric fields on biological cells for bioanalysis, through multiple, independently configurable channels is presented. The programmable system has been used to obtain the dielectrophoretic spectra of cells in near real time, within 90 seconds. This is a significant improvement on existing dielectrophoretic techniques as simultaneous parallel measurement of the dielectrophoretic forces at different frequencies has potential of revealing subtle changes to the electrophysiology of cells, as they occur. The results show that with continuous on-chip monitoring, cells exposed to a chemical agent that induces apoptosis begin to exhibit a spectrum that differs from untreated cells, as indicated from shifts in the observed crossover frequency values.
AB - In this paper, the use of non-uniform ac electric fields on biological cells for bioanalysis, through multiple, independently configurable channels is presented. The programmable system has been used to obtain the dielectrophoretic spectra of cells in near real time, within 90 seconds. This is a significant improvement on existing dielectrophoretic techniques as simultaneous parallel measurement of the dielectrophoretic forces at different frequencies has potential of revealing subtle changes to the electrophysiology of cells, as they occur. The results show that with continuous on-chip monitoring, cells exposed to a chemical agent that induces apoptosis begin to exhibit a spectrum that differs from untreated cells, as indicated from shifts in the observed crossover frequency values.
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U2 - 10.1109/IEMBS.2010.5627083
DO - 10.1109/IEMBS.2010.5627083
M3 - Conference contribution
C2 - 21096494
AN - SCOPUS:78650846773
SN - 9781424441235
T3 - 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
SP - 6510
EP - 6513
BT - 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
T2 - 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Y2 - 31 August 2010 through 4 September 2010
ER -