TY - JOUR
T1 - A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers
AU - Hardie, Rae Anne
AU - Knight, Erin
AU - Bruneau, Brigitte
AU - Semeniuk, Christina
AU - Gill, Kulvinder
AU - Nagelkerke, Nico
AU - Kimani, Joshua
AU - Wachihi, Charles
AU - Ngugi, Elizabeth
AU - Luo, Ma
AU - Plummer, Francis A.
PY - 2008
Y1 - 2008
N2 - A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers parasitic infections and autoimmune diseases, yet its influence on HIV-1 susceptibility has not been well studied. Here, we report several human leucocyte antigen-DP genotypes associated with HIV-1 susceptibility in Kenyan sex workers. Among these, one common genotype stands out. DPA1*010301 (frequency = 60.4%) was associated with HIV-1 resistance (P= 0.033, odds ratio = 1.585, 95% confidence interval = 1.036-2.425) and slower seroconversion (P= 0.001, log rank = 0.595, 95% confidence interval = 0.433-0.817). The discovery of common human leucocyte antigen-DP genotypes contributing to HIV-1 immunity may help overcome difficulties encountered with highly polymorphic human leucocyte antigens.
AB - A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers parasitic infections and autoimmune diseases, yet its influence on HIV-1 susceptibility has not been well studied. Here, we report several human leucocyte antigen-DP genotypes associated with HIV-1 susceptibility in Kenyan sex workers. Among these, one common genotype stands out. DPA1*010301 (frequency = 60.4%) was associated with HIV-1 resistance (P= 0.033, odds ratio = 1.585, 95% confidence interval = 1.036-2.425) and slower seroconversion (P= 0.001, log rank = 0.595, 95% confidence interval = 0.433-0.817). The discovery of common human leucocyte antigen-DP genotypes contributing to HIV-1 immunity may help overcome difficulties encountered with highly polymorphic human leucocyte antigens.
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U2 - 10.1097/QAD.0b013e328311d1a0
DO - 10.1097/QAD.0b013e328311d1a0
M3 - Article
C2 - 18784467
AN - SCOPUS:53549117457
SN - 0269-9370
VL - 22
SP - 2038
EP - 2042
JO - AIDS
JF - AIDS
IS - 15
ER -