A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers

Rae Anne Hardie, Erin Knight, Brigitte Bruneau, Christina Semeniuk, Kulvinder Gill, Nico Nagelkerke, Joshua Kimani, Charles Wachihi, Elizabeth Ngugi, Ma Luo, Francis A. Plummer

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers parasitic infections and autoimmune diseases, yet its influence on HIV-1 susceptibility has not been well studied. Here, we report several human leucocyte antigen-DP genotypes associated with HIV-1 susceptibility in Kenyan sex workers. Among these, one common genotype stands out. DPA1*010301 (frequency = 60.4%) was associated with HIV-1 resistance (P= 0.033, odds ratio = 1.585, 95% confidence interval = 1.036-2.425) and slower seroconversion (P= 0.001, log rank = 0.595, 95% confidence interval = 0.433-0.817). The discovery of common human leucocyte antigen-DP genotypes contributing to HIV-1 immunity may help overcome difficulties encountered with highly polymorphic human leucocyte antigens.

Original languageEnglish
Pages (from-to)2038-2042
Number of pages5
JournalAIDS
Volume22
Issue number15
DOIs
Publication statusPublished - 2008
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers'. Together they form a unique fingerprint.

Cite this