A Concise Synthesis of Pyrrole-Based Drug Candidates from α-Hydroxyketones, 3-Oxobutanenitrile, and Anilines

Mengxin Xia, Mardi Santoso, Ziad Moussa, Zaher M.A. Judeh

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A simple and concise three-component synthesis of a key pyrrole framework was developed from the reaction between α-hydroxyketones, oxoacetonitriles, and anilines. The synthesis was used to obtain several pyrrole-based drug candidates, including COX-2 selective NSAID, antituberculosis lead candidates BM212, BM521, and BM533, as well as several analogues. This route has potential to obtain diverse libraries of these pyrrole candidates in a concise manner to develop optimum lead compounds.

Original languageEnglish
Article number1265
JournalMolecules
Volume28
Issue number3
DOIs
Publication statusPublished - Feb 2023

Keywords

  • BM212
  • pyrroles
  • three-component reactions

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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