The treatment of a piperidinium salt of 6-aryl-5-cyano-2-thiouracil with an O-peracetyl-α-D-pyranosyl bromide produces a mixture of N1-(β-D-pyranosyl)-2-thiouracil and its N1, S2-disubstituted analog. By contrast, the reaction of a silyl derivative of the 2-thiouracil with an O-peracetyl-β-D-pyranose furnishes the mononucleoside selectively. Both the mononucleoside/dinucleoside mixture and pure mononucleoside undergo ammonolysis under mild conditions to give the β-D-nucleoside of 6-aryl-5-cyano-2-thiocytosine. The silyl method also provides an easy access to β-D-ribosyl nucleosides.
- 1 -(β-D-furanosyl)-2-thiocytosines
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry