TY - JOUR
T1 - A fractional-order control model for diabetes with restraining and time-delay
AU - Balakrishnan, Ganesh Priya
AU - Chinnathambi, Rajivganthi
AU - Rihan, Fathalla A.
N1 - Publisher Copyright:
© 2023, The Author(s) under exclusive licence to Korean Society for Informatics and Computational Applied Mathematics.
PY - 2023/8
Y1 - 2023/8
N2 - Even though diabetes is a silent killer and one of the world’s leading public health issues, people can take preventative measures by becoming aware of its causes. This study aims to identify the importance of treatment function and then control the complications of various individuals. We present a mathematical model of diabetes (type-2 diabetes) based on insulin therapy as a controlling factor. With fractional-order delay differential equations, four parts of the population control the dynamic system. The well-posedness (positivity, boundedness) of the model is examined to show that it is biologically and mathematically relevant. According to the characteristics equations for the model, certain sufficient conditions must be met for diabetic-free, endemic equilibrium points to be stable locally. To assess the imbalanced glucose level and treatment over a finite time period, we construct an optimal control problem based on treatment control and awareness program control as time-dependent control parameters. A necessary and sufficient condition for optimality is examined. In order to determine the most cost-effective treatment strategy with limited resources, we assessed the effectiveness and costs of treatments. The theoretical findings are verified by numerical simulations.
AB - Even though diabetes is a silent killer and one of the world’s leading public health issues, people can take preventative measures by becoming aware of its causes. This study aims to identify the importance of treatment function and then control the complications of various individuals. We present a mathematical model of diabetes (type-2 diabetes) based on insulin therapy as a controlling factor. With fractional-order delay differential equations, four parts of the population control the dynamic system. The well-posedness (positivity, boundedness) of the model is examined to show that it is biologically and mathematically relevant. According to the characteristics equations for the model, certain sufficient conditions must be met for diabetic-free, endemic equilibrium points to be stable locally. To assess the imbalanced glucose level and treatment over a finite time period, we construct an optimal control problem based on treatment control and awareness program control as time-dependent control parameters. A necessary and sufficient condition for optimality is examined. In order to determine the most cost-effective treatment strategy with limited resources, we assessed the effectiveness and costs of treatments. The theoretical findings are verified by numerical simulations.
KW - Diabetes
KW - Fractional-order
KW - Optimal control
KW - Stability
KW - Time-delay
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U2 - 10.1007/s12190-023-01885-5
DO - 10.1007/s12190-023-01885-5
M3 - Article
AN - SCOPUS:85163005072
SN - 1598-5865
VL - 69
SP - 3403
EP - 3420
JO - Journal of Applied Mathematics and Computing
JF - Journal of Applied Mathematics and Computing
IS - 4
ER -