A high-resolution comparative radiation hybrid map of equine chromosome 4q12-q22

C. Dierks, S. Mömke, C. Drögemüller, T. Leeb, B. P. Chowdhary, O. Distl

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


In this study, we present a comprehensive 5000-rad radiation hybrid map of a 40-cM region on equine chromosome 4 (ECA4) that contains quantitative trait loci for equine osteochondrosis. We mapped 29 gene-associated sequence tagged site markers using primers designed from equine expressed sequence tags or BAC clones in the ECA4q12-q22 region. Three blocks of conserved synteny, showing two chromosomal breakpoints, were identified in the segment of ECA4q12-q22. Markers from other segments of HSA7q mapped to ECA13p and ECA4p, and a region of HSA7p was homologous to ECA13p. Therefore, we have improved the resolution of the human-equine comparative map, which allows the identification of candidate genes underlying traits of interest.

Original languageEnglish
Pages (from-to)513-517
Number of pages5
JournalAnimal Genetics
Issue number5
Publication statusPublished - Oct 2006
Externally publishedYes


  • Comparative map
  • Equine chromosome 4
  • Equus caballus
  • Fluorescent in situ hybridization
  • Radiation hybrid mapping

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Genetics


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