TY - JOUR
T1 - A hybrid fractional model for cervical cancer due to human papillomavirus infection
AU - Akgül, Ali
AU - Ahmed, Nauman
AU - Rano, Sadiya Ali
AU - Al-Mdallal, Qasem
N1 - Publisher Copyright:
© 2025 The Author(s)
PY - 2025/3
Y1 - 2025/3
N2 - Numerous scientific and engineering applications exist for thermofluids. The primary cause of cervical cancer is the human papillomavirus (HPV), and thermos-fluid is crucial for identifying, treating, and understanding the cancerous phenomenon. In this work, a hybrid fractional order mathematical model of cervical cancer with modified parameters is studied. The proposed model consists of three fractional order nonlinear differential equations. The Grünwald Letnikov method is used to approximate the hybrid operator. A nonstandard finite difference scheme for the GL approximation is obtained to study the proposed model. Stability analysis of the used method is given, existence and uniqueness of solution to the hybrid model are given. Comparative studies between the two schemes is given. Convergence of the state variables is also shown to converge to true equilibrium points according to the stability conditions of the reproductive number. The effect of the order of fractional derivatives can also be observed in the simulations. In the end, concluding remarks are also given in the conclusion section that reflect the whole current research.
AB - Numerous scientific and engineering applications exist for thermofluids. The primary cause of cervical cancer is the human papillomavirus (HPV), and thermos-fluid is crucial for identifying, treating, and understanding the cancerous phenomenon. In this work, a hybrid fractional order mathematical model of cervical cancer with modified parameters is studied. The proposed model consists of three fractional order nonlinear differential equations. The Grünwald Letnikov method is used to approximate the hybrid operator. A nonstandard finite difference scheme for the GL approximation is obtained to study the proposed model. Stability analysis of the used method is given, existence and uniqueness of solution to the hybrid model are given. Comparative studies between the two schemes is given. Convergence of the state variables is also shown to converge to true equilibrium points according to the stability conditions of the reproductive number. The effect of the order of fractional derivatives can also be observed in the simulations. In the end, concluding remarks are also given in the conclusion section that reflect the whole current research.
KW - Grünwald Letnikov approximation
KW - Hybrid fractional operator
KW - NSFD scheme
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U2 - 10.1016/j.ijft.2025.101098
DO - 10.1016/j.ijft.2025.101098
M3 - Article
AN - SCOPUS:85217083876
SN - 2666-2027
VL - 26
JO - International Journal of Thermofluids
JF - International Journal of Thermofluids
M1 - 101098
ER -