A Hybrid of Bees Algorithm and Regulatory On/Off Minimization for Optimizing Lactate Production

Mohd Izzat Yong; Mohd Saberi Mohamad; Yee Wen Choon; Weng Howe Chan; Hasyiya Karimah Adli; Khairul Nizar Syazwan Wsw; Nooraini Yusoff; Muhammad Akmal Remli

doi:10.1007/978-3-030-86258-9_10

A Hybrid of Bees Algorithm and Regulatory On/Off Minimization for Optimizing Lactate Production

Mohd Izzat Yong, Mohd Saberi Mohamad, Yee Wen Choon, Weng Howe Chan, Hasyiya Karimah Adli, Khairul Nizar Syazwan Wsw, Nooraini Yusoff, Muhammad Akmal Remli

Department of Genetics & Genomics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

Metabolic engineering has grown dramatically and is now widely used, particularly in the production of biomass utilising microorganisms. The metabolic network model has been extensively used in computational procedures developed to optimise metabolic production and suggest modifications in organisms. The problem has been the unrealistic flux distribution suggestion demonstrated by previous work on a rational modelling framework employing Optknock and OptGene. To address the issue, a hybrid of the Bees Algorithm and Regulatory On/Off Minimization (BAROOM) is introduced. By using Eschericia coli (E. coli) as the model organism, BAROOM is able to determine the optimal set of gene that can be knocked out and improve lactate production. The results show that BAROOM performs better than other methods in increasing lactate production in model organism by identifying optimal set of genes to be knocked out.

Original language	English
Title of host publication	Practical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021
Editors	Miguel Rocha, Florentino Fdez-Riverola, Mohd Saberi Mohamad, Roberto Casado-Vara
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	95-104
Number of pages	10
ISBN (Print)	9783030862572
DOIs	https://doi.org/10.1007/978-3-030-86258-9_10
Publication status	Published - 2022
Event	15th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2021 - Salamanca, Spain Duration: Oct 6 2021 → Oct 8 2021

Publication series

Name	Lecture Notes in Networks and Systems
Volume	325 LNNS
ISSN (Print)	2367-3370
ISSN (Electronic)	2367-3389

Conference

Conference	15th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2021
Country/Territory	Spain
City	Salamanca
Period	10/6/21 → 10/8/21

Keywords

Artificial Intelligence
Bioinformatics
Gene knockout
Metabolic engineering
Modelling
OptKnock
Optgene
Optimization

ASJC Scopus subject areas

Control and Systems Engineering
Signal Processing
Computer Networks and Communications

Access to Document

10.1007/978-3-030-86258-9_10

Cite this

Yong, M. I., Mohamad, M. S., Choon, Y. W., Chan, W. H., Adli, H. K., Wsw, K. N. S., Yusoff, N., & Remli, M. A. (2022). A Hybrid of Bees Algorithm and Regulatory On/Off Minimization for Optimizing Lactate Production. In M. Rocha, F. Fdez-Riverola, M. S. Mohamad, & R. Casado-Vara (Eds.), Practical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021 (pp. 95-104). (Lecture Notes in Networks and Systems; Vol. 325 LNNS). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-030-86258-9_10

A Hybrid of Bees Algorithm and Regulatory On/Off Minimization for Optimizing Lactate Production. / Yong, Mohd Izzat; Mohamad, Mohd Saberi; Choon, Yee Wen et al.
Practical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021. ed. / Miguel Rocha; Florentino Fdez-Riverola; Mohd Saberi Mohamad; Roberto Casado-Vara. Springer Science and Business Media Deutschland GmbH, 2022. p. 95-104 (Lecture Notes in Networks and Systems; Vol. 325 LNNS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Yong, MI, Mohamad, MS, Choon, YW, Chan, WH, Adli, HK, Wsw, KNS, Yusoff, N & Remli, MA 2022, A Hybrid of Bees Algorithm and Regulatory On/Off Minimization for Optimizing Lactate Production. in M Rocha, F Fdez-Riverola, MS Mohamad & R Casado-Vara (eds), Practical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021. Lecture Notes in Networks and Systems, vol. 325 LNNS, Springer Science and Business Media Deutschland GmbH, pp. 95-104, 15th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2021, Salamanca, Spain, 10/6/21. https://doi.org/10.1007/978-3-030-86258-9_10

Yong MI, Mohamad MS, Choon YW, Chan WH, Adli HK, Wsw KNS et al. A Hybrid of Bees Algorithm and Regulatory On/Off Minimization for Optimizing Lactate Production. In Rocha M, Fdez-Riverola F, Mohamad MS, Casado-Vara R, editors, Practical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021. Springer Science and Business Media Deutschland GmbH. 2022. p. 95-104. (Lecture Notes in Networks and Systems). doi: 10.1007/978-3-030-86258-9_10

Yong, Mohd Izzat ; Mohamad, Mohd Saberi ; Choon, Yee Wen et al. / A Hybrid of Bees Algorithm and Regulatory On/Off Minimization for Optimizing Lactate Production. Practical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021. editor / Miguel Rocha ; Florentino Fdez-Riverola ; Mohd Saberi Mohamad ; Roberto Casado-Vara. Springer Science and Business Media Deutschland GmbH, 2022. pp. 95-104 (Lecture Notes in Networks and Systems).

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A Hybrid of Bees Algorithm and Regulatory On/Off Minimization for Optimizing Lactate Production

Abstract

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Keywords

ASJC Scopus subject areas

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