A Hybrid of Bees Algorithm and Regulatory On/Off Minimization for Optimizing Lactate Production

Mohd Izzat Yong, Mohd Saberi Mohamad, Yee Wen Choon, Weng Howe Chan, Hasyiya Karimah Adli, Khairul Nizar Syazwan Wsw, Nooraini Yusoff, Muhammad Akmal Remli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Metabolic engineering has grown dramatically and is now widely used, particularly in the production of biomass utilising microorganisms. The metabolic network model has been extensively used in computational procedures developed to optimise metabolic production and suggest modifications in organisms. The problem has been the unrealistic flux distribution suggestion demonstrated by previous work on a rational modelling framework employing Optknock and OptGene. To address the issue, a hybrid of the Bees Algorithm and Regulatory On/Off Minimization (BAROOM) is introduced. By using Eschericia coli (E. coli) as the model organism, BAROOM is able to determine the optimal set of gene that can be knocked out and improve lactate production. The results show that BAROOM performs better than other methods in increasing lactate production in model organism by identifying optimal set of genes to be knocked out.

Original languageEnglish
Title of host publicationPractical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021
EditorsMiguel Rocha, Florentino Fdez-Riverola, Mohd Saberi Mohamad, Roberto Casado-Vara
PublisherSpringer Science and Business Media Deutschland GmbH
Pages95-104
Number of pages10
ISBN (Print)9783030862572
DOIs
Publication statusPublished - 2022
Event15th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2021 - Salamanca, Spain
Duration: Oct 6 2021Oct 8 2021

Publication series

NameLecture Notes in Networks and Systems
Volume325 LNNS
ISSN (Print)2367-3370
ISSN (Electronic)2367-3389

Conference

Conference15th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2021
Country/TerritorySpain
CitySalamanca
Period10/6/2110/8/21

Keywords

  • Artificial Intelligence
  • Bioinformatics
  • Gene knockout
  • Metabolic engineering
  • Modelling
  • Optgene
  • Optimization
  • OptKnock

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Signal Processing
  • Computer Networks and Communications

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