A Neurocomputational Analysis Review of Dorsolateral Prefrontal Cortex rTMS Treatments of Neurological Disorder

Hany Alashwal, Julian MacIaszek, Dorota Frydecka, Blazej Misiak, Ahmed A. Moustafa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) has been used as a treatment for several psychiatric and neurological disorders, including depression, bipolar disorder, anxiety, eating disorders, obsessive compulsive disorder, schizophrenia, addiction and Parkinson's disease. However, the precise mechanism of action of DLPFC rTMS and how it translates to the effectiveness of treatment of these disorders is not fully understood. In this study, we provide a review of computational explanations of how DLPFC rTMS may treat several clinical disorders. The review show that DLPFC rTMS can ameliorate several symptoms in different psychiatric and neurological disorders via the following mechanisms of action: (a) modulating the activations of several cortical and subcortical areas, (b) increasing dopamine levels in both cortical and subcortical structures, and (c) modulating connectivity among several brain areas. In addition, we discuss future directions on experimental and computational studies of DLPFC rTMS. Specifically, future computational modelling should take into account the multi-dimensional nature of DLPFC rTMS effect on the brain and behaviour.

Original languageEnglish
Title of host publicationICCBB 2023 - Proceedings of the 2023 7th International Conference on Computational Biology and Bioinformatics
PublisherAssociation for Computing Machinery
Pages85-90
Number of pages6
ISBN (Electronic)9798400716331
DOIs
Publication statusPublished - Dec 11 2023
Event7th International Conference on Computational Biology and Bioinformatics, ICCBB 2023 - Kuala Lumpur, Malaysia
Duration: Dec 11 2023Dec 12 2023

Publication series

NameACM International Conference Proceeding Series

Conference

Conference7th International Conference on Computational Biology and Bioinformatics, ICCBB 2023
Country/TerritoryMalaysia
CityKuala Lumpur
Period12/11/2312/12/23

Keywords

  • Bioinformatics
  • Computational Modelling
  • Neurological disorder
  • repetitive transcranial magnetic stimulation (rTMS)

ASJC Scopus subject areas

  • Human-Computer Interaction
  • Computer Networks and Communications
  • Computer Vision and Pattern Recognition
  • Software

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