A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest

Michael B. Ujiki; Ben Milam; Xian Zhong Ding; Alexandra B. Roginsky; M. Reza Salabat; Mark S. Talamonti; Richard H. Bell; Wenxin Gu; Richard B. Silverman; Thomas E. Adrian

doi:10.1016/j.bbrc.2005.12.131

A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest

Michael B. Ujiki, Ben Milam, Xian Zhong Ding, Alexandra B. Roginsky, M. Reza Salabat, Mark S. Talamonti, Richard H. Bell, Wenxin Gu, Richard B. Silverman, Thomas E. Adrian

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Patients with pancreatic cancer have little hope for cure because no effective therapies are available. Sansalvamide A is a cyclic depsipeptide produced by a marine fungus. We investigated the effect of a novel sansalvamide A analogue on growth, cell-cycle phases, and induction of apoptosis in human pancreatic cancer cells in vitro. The sansalvamide analogue caused marked time- and concentration-dependent inhibition of DNA synthesis and cell proliferation of two human pancreatic cancer cell lines (AsPC-1 and S2-013). The analogue induced G0/G1 phase cell-cycle arrest and morphological changes suggesting induction of apoptosis. Apoptosis was confirmed by annexin V binding. This novel sansalvamide analogue inhibits growth of pancreatic cancer cells through G0/G1 arrest and induces apoptosis. Sansalvamide analogues may be valuable for the treatment of pancreatic cancer.

Original language	English
Pages (from-to)	1224-1228
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	340
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2005.12.131
Publication status	Published - Feb 24 2006
Externally published	Yes

Keywords

Annexin V
Apoptosis
Cell-cycle arrest
Pancreatic cancer
Sansalvamide A

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2005.12.131

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Ujiki, M. B., Milam, B., Ding, X. Z., Roginsky, A. B., Salabat, M. R., Talamonti, M. S., Bell, R. H., Gu, W., Silverman, R. B., & Adrian, T. E. (2006). A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest. Biochemical and Biophysical Research Communications, 340(4), 1224-1228. https://doi.org/10.1016/j.bbrc.2005.12.131

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title = "A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest",

abstract = "Patients with pancreatic cancer have little hope for cure because no effective therapies are available. Sansalvamide A is a cyclic depsipeptide produced by a marine fungus. We investigated the effect of a novel sansalvamide A analogue on growth, cell-cycle phases, and induction of apoptosis in human pancreatic cancer cells in vitro. The sansalvamide analogue caused marked time- and concentration-dependent inhibition of DNA synthesis and cell proliferation of two human pancreatic cancer cell lines (AsPC-1 and S2-013). The analogue induced G0/G1 phase cell-cycle arrest and morphological changes suggesting induction of apoptosis. Apoptosis was confirmed by annexin V binding. This novel sansalvamide analogue inhibits growth of pancreatic cancer cells through G0/G1 arrest and induces apoptosis. Sansalvamide analogues may be valuable for the treatment of pancreatic cancer.",

keywords = "Annexin V, Apoptosis, Cell-cycle arrest, Pancreatic cancer, Sansalvamide A",

author = "Ujiki, {Michael B.} and Ben Milam and Ding, {Xian Zhong} and Roginsky, {Alexandra B.} and Salabat, {M. Reza} and Talamonti, {Mark S.} and Bell, {Richard H.} and Wenxin Gu and Silverman, {Richard B.} and Adrian, {Thomas E.}",

note = "Funding Information: R.B.S. is grateful to the Institute for BioNanotechnology in Medicine at Northwestern University for financial support of this work.",

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doi = "10.1016/j.bbrc.2005.12.131",

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T1 - A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest

AU - Ujiki, Michael B.

AU - Milam, Ben

AU - Ding, Xian Zhong

AU - Roginsky, Alexandra B.

AU - Salabat, M. Reza

AU - Talamonti, Mark S.

AU - Bell, Richard H.

AU - Gu, Wenxin

AU - Silverman, Richard B.

AU - Adrian, Thomas E.

N1 - Funding Information: R.B.S. is grateful to the Institute for BioNanotechnology in Medicine at Northwestern University for financial support of this work.

PY - 2006/2/24

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N2 - Patients with pancreatic cancer have little hope for cure because no effective therapies are available. Sansalvamide A is a cyclic depsipeptide produced by a marine fungus. We investigated the effect of a novel sansalvamide A analogue on growth, cell-cycle phases, and induction of apoptosis in human pancreatic cancer cells in vitro. The sansalvamide analogue caused marked time- and concentration-dependent inhibition of DNA synthesis and cell proliferation of two human pancreatic cancer cell lines (AsPC-1 and S2-013). The analogue induced G0/G1 phase cell-cycle arrest and morphological changes suggesting induction of apoptosis. Apoptosis was confirmed by annexin V binding. This novel sansalvamide analogue inhibits growth of pancreatic cancer cells through G0/G1 arrest and induces apoptosis. Sansalvamide analogues may be valuable for the treatment of pancreatic cancer.

AB - Patients with pancreatic cancer have little hope for cure because no effective therapies are available. Sansalvamide A is a cyclic depsipeptide produced by a marine fungus. We investigated the effect of a novel sansalvamide A analogue on growth, cell-cycle phases, and induction of apoptosis in human pancreatic cancer cells in vitro. The sansalvamide analogue caused marked time- and concentration-dependent inhibition of DNA synthesis and cell proliferation of two human pancreatic cancer cell lines (AsPC-1 and S2-013). The analogue induced G0/G1 phase cell-cycle arrest and morphological changes suggesting induction of apoptosis. Apoptosis was confirmed by annexin V binding. This novel sansalvamide analogue inhibits growth of pancreatic cancer cells through G0/G1 arrest and induces apoptosis. Sansalvamide analogues may be valuable for the treatment of pancreatic cancer.

KW - Annexin V

KW - Apoptosis

KW - Cell-cycle arrest

KW - Pancreatic cancer

KW - Sansalvamide A

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A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest

Abstract

Keywords

ASJC Scopus subject areas

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