A population-based study on tetanus antitoxin levels in the Netherlands

H. E. De Melker, S. Van Den Hof, G. A.M. Berbers, N. J.D. Nagelkerke, M. A.E. Conyn-Van Spaendonck

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


We assessed the tetanus immunity of the general Dutch population and of religious groups refusing vaccination by means of population-based study to evaluate the effect of tetanus vaccination. More than 95% of those born after the introduction of routine vaccination had tetanus antitoxin levels above the minimum protective level. After the sixth vaccination, a fall in tetanus antitoxin levels occurred. Nevertheless, immunisation in accordance with the routine programme most likely induces protection for much longer than two decades. Not only many members of religious groups who refuse vaccination, but also many adults born before the introduction of vaccination lack tetanus immunity. These cohorts might benefit most from (re)vaccination.

Original languageEnglish
Pages (from-to)100-108
Number of pages9
Issue number1-2
Publication statusPublished - Aug 20 1999
Externally publishedYes


  • Evaluation of vaccination
  • Population-based study
  • Tetanus antitoxin levels

ASJC Scopus subject areas

  • Molecular Medicine
  • General Immunology and Microbiology
  • General Veterinary
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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