A population-based study on tetanus antitoxin levels in the Netherlands

H. E. De Melker; S. Van Den Hof; G. A.M. Berbers; N. J.D. Nagelkerke; M. A.E. Conyn-Van Spaendonck

doi:10.1016/S0264-410X(99)00186-3

A population-based study on tetanus antitoxin levels in the Netherlands

H. E. De Melker
, S. Van Den Hof
, G. A.M. Berbers
, N. J.D. Nagelkerke
, M. A.E. Conyn-Van Spaendonck

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

We assessed the tetanus immunity of the general Dutch population and of religious groups refusing vaccination by means of population-based study to evaluate the effect of tetanus vaccination. More than 95% of those born after the introduction of routine vaccination had tetanus antitoxin levels above the minimum protective level. After the sixth vaccination, a fall in tetanus antitoxin levels occurred. Nevertheless, immunisation in accordance with the routine programme most likely induces protection for much longer than two decades. Not only many members of religious groups who refuse vaccination, but also many adults born before the introduction of vaccination lack tetanus immunity. These cohorts might benefit most from (re)vaccination.

Original language	English
Pages (from-to)	100-108
Number of pages	9
Journal	Vaccine
Volume	18
Issue number	1-2
DOIs	https://doi.org/10.1016/S0264-410X(99)00186-3
Publication status	Published - Aug 20 1999
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Evaluation of vaccination
Population-based study
Tetanus antitoxin levels

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

Access to Document

10.1016/S0264-410X(99)00186-3

Cite this

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abstract = "We assessed the tetanus immunity of the general Dutch population and of religious groups refusing vaccination by means of population-based study to evaluate the effect of tetanus vaccination. More than 95\% of those born after the introduction of routine vaccination had tetanus antitoxin levels above the minimum protective level. After the sixth vaccination, a fall in tetanus antitoxin levels occurred. Nevertheless, immunisation in accordance with the routine programme most likely induces protection for much longer than two decades. Not only many members of religious groups who refuse vaccination, but also many adults born before the introduction of vaccination lack tetanus immunity. These cohorts might benefit most from (re)vaccination.",

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AU - De Melker, H. E.

AU - Van Den Hof, S.

AU - Berbers, G. A.M.

AU - Nagelkerke, N. J.D.

AU - Conyn-Van Spaendonck, M. A.E.

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A population-based study on tetanus antitoxin levels in the Netherlands

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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