A synthesis of puraquinonic acid

Soleiman Hisaindee; Derrick L.J. Clive

doi:10.1016/S0040-4039(01)00144-7

A synthesis of puraquinonic acid

Soleiman Hisaindee
, Derrick L.J. Clive

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

2-Methyl-1,4-benzenediol (10) was acylated with α-chloroisobutyroyl chloride and converted by treatment with AlCl₃ into the indanone derivative 12, which was elaborated into the substituted indane acid 24. Oxidation then afforded racemic puraquinonic acid.

Original language	English
Pages (from-to)	2253-2255
Number of pages	3
Journal	Tetrahedron Letters
Volume	42
Issue number	12
DOIs	https://doi.org/10.1016/S0040-4039(01)00144-7
Publication status	Published - Mar 18 2001
Externally published	Yes

Keywords

Antileukemia compound
Claisen rearrangement
Differentiation inducer
Oxidation
Quinone

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)00144-7

Cite this

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title = "A synthesis of puraquinonic acid",

abstract = "2-Methyl-1,4-benzenediol (10) was acylated with α-chloroisobutyroyl chloride and converted by treatment with AlCl3 into the indanone derivative 12, which was elaborated into the substituted indane acid 24. Oxidation then afforded racemic puraquinonic acid.",

keywords = "Antileukemia compound, Claisen rearrangement, Differentiation inducer, Oxidation, Quinone",

author = "Soleiman Hisaindee and Clive, \{Derrick L.J.\}",

note = "Funding Information: Acknowledgment is made to the Natural Sciences and Engineering Research Council of Canada and to AnorMED (Langley, BC) for financial support.",

year = "2001",

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doi = "10.1016/S0040-4039(01)00144-7",

language = "English",

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pages = "2253--2255",

journal = "Tetrahedron Letters",

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T1 - A synthesis of puraquinonic acid

AU - Hisaindee, Soleiman

AU - Clive, Derrick L.J.

N1 - Funding Information: Acknowledgment is made to the Natural Sciences and Engineering Research Council of Canada and to AnorMED (Langley, BC) for financial support.

PY - 2001/3/18

Y1 - 2001/3/18

N2 - 2-Methyl-1,4-benzenediol (10) was acylated with α-chloroisobutyroyl chloride and converted by treatment with AlCl3 into the indanone derivative 12, which was elaborated into the substituted indane acid 24. Oxidation then afforded racemic puraquinonic acid.

AB - 2-Methyl-1,4-benzenediol (10) was acylated with α-chloroisobutyroyl chloride and converted by treatment with AlCl3 into the indanone derivative 12, which was elaborated into the substituted indane acid 24. Oxidation then afforded racemic puraquinonic acid.

KW - Antileukemia compound

KW - Claisen rearrangement

KW - Differentiation inducer

KW - Oxidation

KW - Quinone

UR - https://www.scopus.com/pages/publications/0035906079

UR - https://www.scopus.com/pages/publications/0035906079#tab=citedBy

U2 - 10.1016/S0040-4039(01)00144-7

DO - 10.1016/S0040-4039(01)00144-7

M3 - Article

AN - SCOPUS:0035906079

SN - 0040-4039

VL - 42

SP - 2253

EP - 2255

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 12

ER -

A synthesis of puraquinonic acid

Abstract

Keywords

ASJC Scopus subject areas

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