A three-stage method to select informative genes for cancer classification

Mohd Saberi Mohamad, Sigeru Omatu, Michifumi Yoshioka, Safaai Deris

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Microarray technology has provided biologists with the ability to measure the expression levels of thousands of genes in a single experiment. One of the urgent issues in the use of microarray data is the selection of a small subset of genes from the thousands of genes in the data that contributes to a disease. This selection process is difficult due to many irrelevant genes, noisy genes, and the availability of the small number of samples compared to the huge number of genes (high-dimensional data). In this study, we propose a three-stage gene selection method to select a small subset of informative genes that is most relevant for the cancer classification. It has three stages: 1) pre-selecting genes using a filter method to produce a subset of genes; 2) optimising the gene subset using a multi-objective hybrid method to yield near-optimal gene subsets; 3) analyzing the frequency of appearance of each gene in the different near-optimal gene subsets to produce a small subset of informative genes. The experimental results show that our proposed method is capable in selecting the small subset to obtain better classification accuracies than other related previous works as well as five methods experimented in this work. Additionally, a list of informative genes in the final gene subsets is also presented for biological usage.

Original languageEnglish
Pages (from-to)117-125
Number of pages9
JournalInternational Journal of Innovative Computing, Information and Control
Volume6
Issue number1
Publication statusPublished - Jan 2010
Externally publishedYes

Keywords

  • A three-stage method
  • Gene selection
  • Hybrid approach
  • Microarray data

ASJC Scopus subject areas

  • Software
  • Theoretical Computer Science
  • Information Systems
  • Computational Theory and Mathematics

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