Abundance of VIP in duodenal mucosa of coeliacs and duodenal ulcer patients

S. Domschke, S. R. Bloom, T. E. Adrian, G. Lux, M. G. Bryant, W. Domschke

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


VIP levels were determined in gastroduodenal mucosal biopsies of 8 duodenal ulcer patients, of 5 coeliac sprue patients, and of 8 volunteers without upper gastrointestinal disease. In duodenal ulcer patients, mucosal VIP concentrations were significantly elevated in the proximal duodenum (e.g., in the duodenal bulb 225±48 versus 95±17 pmol/g in controls), while in coeliac sprue VIP levels tended to be increased in the whole duodenum and upper jejunum (e.g., descending duodenum 409±161 versus 81±16, p<0.05). In both disease entities, the rise in mucosal VIP may be a reaction of the peptidergic nervous system to chronic mucosal irritation and a reason for enhanced fluid and electrolyte secretion in the affected areas.

Original languageEnglish
Pages (from-to)411-413
Number of pages3
Issue number2
Publication statusPublished - 1984
Externally publishedYes


  • Coeliac sprue
  • Duodenal ulcer
  • Duodenitis
  • Gastroduodenal mucosa
  • Substance P
  • Vasoactive intestinal peptide

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience


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