Abundance of VIP in duodenal mucosa of coeliacs and duodenal ulcer patients

S. Domschke; S. R. Bloom; T. E. Adrian; G. Lux; M. G. Bryant; W. Domschke

doi:10.1016/0196-9781(84)90245-6

Abundance of VIP in duodenal mucosa of coeliacs and duodenal ulcer patients

S. Domschke, S. R. Bloom, T. E. Adrian, G. Lux, M. G. Bryant, W. Domschke

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

VIP levels were determined in gastroduodenal mucosal biopsies of 8 duodenal ulcer patients, of 5 coeliac sprue patients, and of 8 volunteers without upper gastrointestinal disease. In duodenal ulcer patients, mucosal VIP concentrations were significantly elevated in the proximal duodenum (e.g., in the duodenal bulb 225±48 versus 95±17 pmol/g in controls), while in coeliac sprue VIP levels tended to be increased in the whole duodenum and upper jejunum (e.g., descending duodenum 409±161 versus 81±16, p<0.05). In both disease entities, the rise in mucosal VIP may be a reaction of the peptidergic nervous system to chronic mucosal irritation and a reason for enhanced fluid and electrolyte secretion in the affected areas.

Original language	English
Pages (from-to)	411-413
Number of pages	3
Journal	Peptides
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/0196-9781(84)90245-6
Publication status	Published - Jan 1 1984
Externally published	Yes

Keywords

Coeliac sprue
Duodenal ulcer
Duodenitis
Gastroduodenal mucosa
Substance P
Vasoactive intestinal peptide

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(84)90245-6

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title = "Abundance of VIP in duodenal mucosa of coeliacs and duodenal ulcer patients",

abstract = "VIP levels were determined in gastroduodenal mucosal biopsies of 8 duodenal ulcer patients, of 5 coeliac sprue patients, and of 8 volunteers without upper gastrointestinal disease. In duodenal ulcer patients, mucosal VIP concentrations were significantly elevated in the proximal duodenum (e.g., in the duodenal bulb 225±48 versus 95±17 pmol/g in controls), while in coeliac sprue VIP levels tended to be increased in the whole duodenum and upper jejunum (e.g., descending duodenum 409±161 versus 81±16, p<0.05). In both disease entities, the rise in mucosal VIP may be a reaction of the peptidergic nervous system to chronic mucosal irritation and a reason for enhanced fluid and electrolyte secretion in the affected areas.",

keywords = "Coeliac sprue, Duodenal ulcer, Duodenitis, Gastroduodenal mucosa, Substance P, Vasoactive intestinal peptide",

author = "S. Domschke and Bloom, {S. R.} and Adrian, {T. E.} and G. Lux and Bryant, {M. G.} and W. Domschke",

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T1 - Abundance of VIP in duodenal mucosa of coeliacs and duodenal ulcer patients

AU - Domschke, S.

AU - Bloom, S. R.

AU - Adrian, T. E.

AU - Lux, G.

AU - Bryant, M. G.

AU - Domschke, W.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - VIP levels were determined in gastroduodenal mucosal biopsies of 8 duodenal ulcer patients, of 5 coeliac sprue patients, and of 8 volunteers without upper gastrointestinal disease. In duodenal ulcer patients, mucosal VIP concentrations were significantly elevated in the proximal duodenum (e.g., in the duodenal bulb 225±48 versus 95±17 pmol/g in controls), while in coeliac sprue VIP levels tended to be increased in the whole duodenum and upper jejunum (e.g., descending duodenum 409±161 versus 81±16, p<0.05). In both disease entities, the rise in mucosal VIP may be a reaction of the peptidergic nervous system to chronic mucosal irritation and a reason for enhanced fluid and electrolyte secretion in the affected areas.

AB - VIP levels were determined in gastroduodenal mucosal biopsies of 8 duodenal ulcer patients, of 5 coeliac sprue patients, and of 8 volunteers without upper gastrointestinal disease. In duodenal ulcer patients, mucosal VIP concentrations were significantly elevated in the proximal duodenum (e.g., in the duodenal bulb 225±48 versus 95±17 pmol/g in controls), while in coeliac sprue VIP levels tended to be increased in the whole duodenum and upper jejunum (e.g., descending duodenum 409±161 versus 81±16, p<0.05). In both disease entities, the rise in mucosal VIP may be a reaction of the peptidergic nervous system to chronic mucosal irritation and a reason for enhanced fluid and electrolyte secretion in the affected areas.

KW - Coeliac sprue

KW - Duodenal ulcer

KW - Duodenitis

KW - Gastroduodenal mucosa

KW - Substance P

KW - Vasoactive intestinal peptide

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Abundance of VIP in duodenal mucosa of coeliacs and duodenal ulcer patients

Abstract

Keywords

ASJC Scopus subject areas

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