Acetyl-l-carnitine reduces the infarct size and striatal glutamate outflow following focal cerebral ischemia in rats

Fakhreya Yousuf Jalal, Mark Böhlke, Timothy J. Maher

Research output: Chapter in Book/Report/Conference proceedingConference contribution

26 Citations (Scopus)

Abstract

Acetyl-l-carnitine (ALCAR), an endogenous water soluble molecule, is synthesized in the brain and is involved in many aspects of neuronal activity, including metabolism and neuronal membrane formation and integrity. To determine ALCAR's neuroprotective effects, focal cerebral ischemia was induced using four models of middle cerebral artery occlusion (MCAO) and treatment with 0-400 mgkg ALCAR (i.p.) prior to MCAO. While acute doses were without effect, pretreatment with chronic ALCAR (400 mgkgday for five days) significantly reduced infarct size. Lower chronic ALCAR doses were not effective. Additionally, elevations in microdialysate glutamate post-MCAO were attenuated by ALCAR treatment.

Original languageEnglish
Title of host publicationNeuroprotective Agents
Subtitle of host publicationNinth International Conference
PublisherBlackwell Publishing Inc.
Pages95-104
Number of pages10
ISBN (Print)9781573317771
DOIs
Publication statusPublished - Jun 2010
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1199
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • ALCAR
  • cerebral ischemia
  • glutamate
  • infarct size
  • microdialysis
  • stroke

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry,Genetics and Molecular Biology
  • History and Philosophy of Science

Fingerprint

Dive into the research topics of 'Acetyl-l-carnitine reduces the infarct size and striatal glutamate outflow following focal cerebral ischemia in rats'. Together they form a unique fingerprint.

Cite this