Acetyl-l-carnitine reduces the infarct size and striatal glutamate outflow following focal cerebral ischemia in rats

Fakhreya Yousuf Jalal; Mark Böhlke; Timothy J. Maher

doi:10.1111/j.1749-6632.2009.05351.x

Acetyl-l-carnitine reduces the infarct size and striatal glutamate outflow following focal cerebral ischemia in rats

Fakhreya Yousuf Jalal, Mark Böhlke, Timothy J. Maher

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

26 Citations (Scopus)

Abstract

Acetyl-l-carnitine (ALCAR), an endogenous water soluble molecule, is synthesized in the brain and is involved in many aspects of neuronal activity, including metabolism and neuronal membrane formation and integrity. To determine ALCAR's neuroprotective effects, focal cerebral ischemia was induced using four models of middle cerebral artery occlusion (MCAO) and treatment with 0-400 mgkg ALCAR (i.p.) prior to MCAO. While acute doses were without effect, pretreatment with chronic ALCAR (400 mgkgday for five days) significantly reduced infarct size. Lower chronic ALCAR doses were not effective. Additionally, elevations in microdialysate glutamate post-MCAO were attenuated by ALCAR treatment.

Original language	English
Title of host publication	Neuroprotective Agents
Subtitle of host publication	Ninth International Conference
Publisher	Blackwell Publishing Inc.
Pages	95-104
Number of pages	10
ISBN (Print)	9781573317771
DOIs	https://doi.org/10.1111/j.1749-6632.2009.05351.x
Publication status	Published - Jun 2010
Externally published	Yes

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1199
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

Keywords

ALCAR
cerebral ischemia
glutamate
infarct size
microdialysis
stroke

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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10.1111/j.1749-6632.2009.05351.x

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Jalal, F. Y., Böhlke, M., & Maher, T. J. (2010). Acetyl-l-carnitine reduces the infarct size and striatal glutamate outflow following focal cerebral ischemia in rats. In Neuroprotective Agents: Ninth International Conference (pp. 95-104). (Annals of the New York Academy of Sciences; Vol. 1199). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.05351.x

Acetyl-l-carnitine reduces the infarct size and striatal glutamate outflow following focal cerebral ischemia in rats. / Jalal, Fakhreya Yousuf; Böhlke, Mark; Maher, Timothy J.
Neuroprotective Agents: Ninth International Conference. Blackwell Publishing Inc., 2010. p. 95-104 (Annals of the New York Academy of Sciences; Vol. 1199).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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abstract = "Acetyl-l-carnitine (ALCAR), an endogenous water soluble molecule, is synthesized in the brain and is involved in many aspects of neuronal activity, including metabolism and neuronal membrane formation and integrity. To determine ALCAR's neuroprotective effects, focal cerebral ischemia was induced using four models of middle cerebral artery occlusion (MCAO) and treatment with 0-400 mgkg ALCAR (i.p.) prior to MCAO. While acute doses were without effect, pretreatment with chronic ALCAR (400 mgkgday for five days) significantly reduced infarct size. Lower chronic ALCAR doses were not effective. Additionally, elevations in microdialysate glutamate post-MCAO were attenuated by ALCAR treatment.",

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Acetyl-l-carnitine reduces the infarct size and striatal glutamate outflow following focal cerebral ischemia in rats

Abstract

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Keywords

ASJC Scopus subject areas

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