Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines

Louise A. Rollins-Smith; Cynthia Carey; J. Michael Conlon; Laura K. Reinert; Jennifer K. Doersam; Tomas Bergman; Jerzy Silberring; Hilkka Lankinen; David Wade

doi:10.1128/AAC.47.3.1157-1160.2003

Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines

Louise A. Rollins-Smith
, Cynthia Carey
, J. Michael Conlon
, Laura K. Reinert
, Jennifer K. Doersam
, Tomas Bergman
, Jerzy Silberring
, Hilkka Lankinen
, David Wade

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Temporin A and structurally related peptides produced in amphibian dermal granular glands and in wasp venom were tested for growth inhibition of Batrachochytrium dendrobatidis, a pathogen associated with global amphibian declines. Two natural amphibian temporins, a wasp temporin, and six synthetic analogs effectively inhibited growth. Differences in potency due to amino acid substitution suggest that ability to penetrate membranes and form an α-helical structure is important for their effectiveness against this pathogen.

Original language	English
Pages (from-to)	1157-1160
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	47
Issue number	3
DOIs	https://doi.org/10.1128/AAC.47.3.1157-1160.2003
Publication status	Published - Mar 3 2003
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.47.3.1157-1160.2003

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Rollins-Smith, L. A., Carey, C., Conlon, J. M., Reinert, L. K., Doersam, J. K., Bergman, T., Silberring, J., Lankinen, H., & Wade, D. (2003). Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines. Antimicrobial Agents and Chemotherapy, 47(3), 1157-1160. https://doi.org/10.1128/AAC.47.3.1157-1160.2003

Rollins-Smith, LA, Carey, C, Conlon, JM, Reinert, LK, Doersam, JK, Bergman, T, Silberring, J, Lankinen, H & Wade, D 2003, 'Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines', Antimicrobial Agents and Chemotherapy, vol. 47, no. 3, pp. 1157-1160. https://doi.org/10.1128/AAC.47.3.1157-1160.2003

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AU - Reinert, Laura K.

AU - Doersam, Jennifer K.

AU - Bergman, Tomas

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Activities of temporin family peptides against the chytrid fungus (Batrachochytrium dendrobatidis) associated with global amphibian declines

Abstract

ASJC Scopus subject areas

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