TY - JOUR
T1 - Acute kidney injury secondary to renal large B-cell lymphoma
T2 - Role of early renal biopsy
AU - Al-Salam, Suhail
AU - Shaaban, Ahmad
AU - Alketbi, Maha
AU - Haq, Naveed U.
AU - Abouchacra, Samra
PY - 2011/3
Y1 - 2011/3
N2 - Renal involvement in large B-cell lymphoma represents an exceptional manifestation of non-Hodgkin lymphomas. Acute kidney injury (AKI) by lymphomatous infiltration is extremely rare and so far only 19 cases have been reported in the literature. We report a 67-year-old woman who presented with AKI and was found to have large B-cell lymphoma infiltrating her kidneys. The patient was treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with rituximab, and a dramatic improvement of renal function was noticed after two weeks of treatment. Her renal function completely recovered after four weeks of treatment. In conclusion, lymphomatous infiltration of kidneys can directly lead to AKI. Rapid diagnosis and treatment is essential to preserve the renal function. Renal biopsy is the gold standard for the early diagnosis of non-Hodgkin lymphoma as a cause of AKI.
AB - Renal involvement in large B-cell lymphoma represents an exceptional manifestation of non-Hodgkin lymphomas. Acute kidney injury (AKI) by lymphomatous infiltration is extremely rare and so far only 19 cases have been reported in the literature. We report a 67-year-old woman who presented with AKI and was found to have large B-cell lymphoma infiltrating her kidneys. The patient was treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with rituximab, and a dramatic improvement of renal function was noticed after two weeks of treatment. Her renal function completely recovered after four weeks of treatment. In conclusion, lymphomatous infiltration of kidneys can directly lead to AKI. Rapid diagnosis and treatment is essential to preserve the renal function. Renal biopsy is the gold standard for the early diagnosis of non-Hodgkin lymphoma as a cause of AKI.
KW - Acute kidney injury
KW - Kidney
KW - Non-Hodgkin lymphoma
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U2 - 10.1007/s11255-010-9728-5
DO - 10.1007/s11255-010-9728-5
M3 - Article
C2 - 20354901
AN - SCOPUS:79953820299
SN - 0301-1623
VL - 43
SP - 237
EP - 240
JO - International Urology and Nephrology
JF - International Urology and Nephrology
IS - 1
ER -