TY - JOUR
T1 - Acute sexually transmitted infections increase human immunodeficiency virus type 1 plasma viremia, increase plasma type 2 cytokines, and decrease CD4 cell counts
AU - Anzala, A. O.
AU - Simonsen, J. N.
AU - Kimani, J.
AU - Ball, T. B.
AU - Nagelkerke, N. J.D.
AU - Rutherford, J.
AU - Ngugi, E. N.
AU - Bwayo, J. J.
AU - Plummer, F. A.
N1 - Funding Information:
Financial support: Medical Research Council of Canada (GR 13301) and the Rockefeller Foundation. F.A.P. is Medical Research Council of Canada Senior Scientist. J.N.S. was an American Foundation for AIDS Research scholar. A.O.A. received scholarships from the Rockefeller Foundation and the Canadian International Development Agency.
PY - 2000
Y1 - 2000
N2 - In Kenya, the median incubation time to AIDS in seroconverting sex workers is 4 years; this incubation time is specific to female sex workers. We studied the influence of acute sexually transmitted infections (STIs) on several immunologic parameters in 32 human immunodeficiency virus type 1 (HIV-1)-positive and 10 HIV-1-negative women sex workers who were followed for 1-5 months. Plasma cytokines, soluble cytokine receptors, CD4 and CD8 T cell counts, and HIV-1 plasma viremia were quantitated before, during, and after episodes of STI. Increases in interleukin (IL)-4, IL-6, IL-10, soluble tumor necrosis factor (TNF)-α, and viremia and a decline in CD4+ T cell counts occurred during gonococcal cervicitis and returned to baseline after treatment. Increases in viremia correlated with increased IL-4 and decreased IL-6 concentrations. Similar changes were seen among women with acute pelvic inflammatory disease. Acute bacterial STI resulted in increased HIV-1 viremia. This may be mediated through increased inflammatory cytokines or through modulation of immune responses that control HIV-1 viremia.
AB - In Kenya, the median incubation time to AIDS in seroconverting sex workers is 4 years; this incubation time is specific to female sex workers. We studied the influence of acute sexually transmitted infections (STIs) on several immunologic parameters in 32 human immunodeficiency virus type 1 (HIV-1)-positive and 10 HIV-1-negative women sex workers who were followed for 1-5 months. Plasma cytokines, soluble cytokine receptors, CD4 and CD8 T cell counts, and HIV-1 plasma viremia were quantitated before, during, and after episodes of STI. Increases in interleukin (IL)-4, IL-6, IL-10, soluble tumor necrosis factor (TNF)-α, and viremia and a decline in CD4+ T cell counts occurred during gonococcal cervicitis and returned to baseline after treatment. Increases in viremia correlated with increased IL-4 and decreased IL-6 concentrations. Similar changes were seen among women with acute pelvic inflammatory disease. Acute bacterial STI resulted in increased HIV-1 viremia. This may be mediated through increased inflammatory cytokines or through modulation of immune responses that control HIV-1 viremia.
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U2 - 10.1086/315733
DO - 10.1086/315733
M3 - Article
C2 - 10915076
AN - SCOPUS:0033845129
SN - 0022-1899
VL - 182
SP - 459
EP - 466
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -