TY - JOUR
T1 - Adiponectin is associated with lipid profile and insulin sensitivity in French adolescents
AU - Wagner, A.
AU - Simon, C.
AU - Oujaa, M.
AU - Platat, C.
AU - Schweitzer, B.
AU - Arveiler, D.
N1 - Funding Information:
This study was supported by grants from the Regional Health Insurance of Alsace-Moselle and the National Programme for Research in Human Nutrition (Inserm and INRA). The authors wish to thank F. Goupilleau and the EA 3072 department (Louis Pasteur University of Strasbourg) for the adiponectin measurements, and F. Ghazlane for her technical assistance.
PY - 2008/11
Y1 - 2008/11
N2 - Aim: The favourable relationship of adiponectin with the metabolic profile demonstrated in adults has been less studied in youths. The aim of this study was to examine cross-sectional and longitudinal associations between adiponectin and various metabolic risk factors in 12-year-old adolescents. Methods: Subjects were participants in a randomized controlled study to promote physical activity (PA). Cross-sectional associations were assessed at entry in 2002 among 647 PA-exposed and control first-level students (49% male, 11.6 ± 0.6 years of age). Longitudinal analyses involved 288 control students surveyed in 2002 and 2004. Baseline measurements included fasting serum adiponectin and anthropometric indices (body mass, waist size, body fat [BF] by bioimpedance), insulin concentration, homeostasis model assessment (HOMA), high-density lipoprotein (HDL) cholesterol, triglycerides (TG), soluble TNF-α receptor 1 (sTNF-α R1) and high-sensitivity C-reactive protein. Analyses were performed with generalized linear mixed-effects models, taking into account correlations among adolescents in the same school. Results: Cross-sectionally, plasma adiponectin was inversely associated with obesity indices, especially waist size (P < 10-2), HOMA (P < 0.03), insulin (P < 0.04), TG (P < 10-2) and sTNF-α R1 (P < 0.05), and positively related to HDL cholesterol (P < 10-4), after adjusting for age, gender, sexual maturity, sports participation and adiposity when relevant. Longitudinally, a higher baseline adiponectin level was associated with a more favourable two-year change in TG (P < 0.05), even after accounting for baseline TG, and two-year BF and insulin changes. Conclusion: The findings of this study suggest a favourable relationship between adiponectin and both metabolic profile and subsequent changes in TG level in young adolescents.
AB - Aim: The favourable relationship of adiponectin with the metabolic profile demonstrated in adults has been less studied in youths. The aim of this study was to examine cross-sectional and longitudinal associations between adiponectin and various metabolic risk factors in 12-year-old adolescents. Methods: Subjects were participants in a randomized controlled study to promote physical activity (PA). Cross-sectional associations were assessed at entry in 2002 among 647 PA-exposed and control first-level students (49% male, 11.6 ± 0.6 years of age). Longitudinal analyses involved 288 control students surveyed in 2002 and 2004. Baseline measurements included fasting serum adiponectin and anthropometric indices (body mass, waist size, body fat [BF] by bioimpedance), insulin concentration, homeostasis model assessment (HOMA), high-density lipoprotein (HDL) cholesterol, triglycerides (TG), soluble TNF-α receptor 1 (sTNF-α R1) and high-sensitivity C-reactive protein. Analyses were performed with generalized linear mixed-effects models, taking into account correlations among adolescents in the same school. Results: Cross-sectionally, plasma adiponectin was inversely associated with obesity indices, especially waist size (P < 10-2), HOMA (P < 0.03), insulin (P < 0.04), TG (P < 10-2) and sTNF-α R1 (P < 0.05), and positively related to HDL cholesterol (P < 10-4), after adjusting for age, gender, sexual maturity, sports participation and adiposity when relevant. Longitudinally, a higher baseline adiponectin level was associated with a more favourable two-year change in TG (P < 0.05), even after accounting for baseline TG, and two-year BF and insulin changes. Conclusion: The findings of this study suggest a favourable relationship between adiponectin and both metabolic profile and subsequent changes in TG level in young adolescents.
KW - Adiponectin
KW - Adolescents
KW - Insulin resistance
KW - Lipid profile
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U2 - 10.1016/j.diabet.2008.02.006
DO - 10.1016/j.diabet.2008.02.006
M3 - Article
C2 - 18684654
AN - SCOPUS:55949098381
SN - 1262-3636
VL - 34
SP - 465
EP - 471
JO - Diabetes and Metabolism
JF - Diabetes and Metabolism
IS - 5
ER -