Advances in Zika virus vaccines and therapeutics: A systematic review

Shiza Malik, Khalid Muhammad, Omar Ahsan, Muhammad Tahir Khan, Ranjit Sah, Yasir Waheed

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Zika virus (ZIKV) is the causative agent of a viral infection that causes neurological complications in newborns and adults worldwide. Its wide transmission route and alarming spread rates are of great concern to the scientific community. Numerous trials have been conducted to develop treatment options for ZIKV infection. This review highlights the latest developments in the fields of vaccinology and pharmaceuticals developments for ZIKV infection. A systematic and comprehensive approach was used to gather relevant and up-to-date data so that inferences could be made about the gaps in therapeutic development. The results indicate that several therapeutic interventions are being tested against ZIKV infection, such as DNA vaccines, subunit vaccines, live-attenuated vaccines, virus-vector-based vaccines, inactivated vaccines, virus-like particles, and mRNA-based vaccines. In addition, approved anti-ZIKV drugs that can reduce the global burden are discussed. Although many vaccine candidates for ZIKV are at different stages of development, none of them have received Food and Drug Authority approval for use up to now. The issue of side effects associated with these drugs in vulnerable newborns and pregnant women is a major obstacle in the therapeutic pathway.

Original languageEnglish
Pages (from-to)97-109
Number of pages13
JournalAsian Pacific Journal of Tropical Medicine
Issue number3
Publication statusPublished - Mar 2024


  • Antiviral agents
  • Clinical management
  • Infection
  • Novel therapeutic
  • Therapeutics
  • Therapies
  • Treatment
  • Vaccines
  • Zika virus

ASJC Scopus subject areas

  • General Medicine


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