TY - JOUR
T1 - AI-driven Q-learning for personalized acne genetics
T2 - Innovative approaches and potential genetic markers
AU - Chua, Yong Chi
AU - Nies, Hui Wen
AU - Kamsani, Izyan Izzati
AU - Hashim, Haslina
AU - Yusoff, Yusliza
AU - Chan, Weng Howe
AU - Remli, Muhammad Akmal
AU - Nies, Yong Hui
AU - Mohamad, Mohd Saberi
N1 - Publisher Copyright:
© 2024
PY - 2024/6
Y1 - 2024/6
N2 - Genetic markers for acne are being studied to create personalized treatments based on an individual's genes, and the field is benefiting from the application of artificial intelligence (AI) techniques. One such AI tool, the Q-learning algorithm, is increasingly being utilized by medical researchers to delve into the genetics of acne. In contrast to previous methods, our research introduces a Q-learning model that is adaptable to diverse sample groups. This innovative approach involves preprocessing data by identifying differentially expressed genes and constructing gene-gene connectivity networks. The key advantage of using the Q-learning model lies in its ability to transform acne gene data into Markovian domains, which are essential for selecting relevant genetic markers. Performance evaluations of our Q-learning model have shown high accuracy and specificity, although there may be some sensitivity variations. Notably, this research has identified specific genes, such as CD86, AGPAT3, TMPRSS11D, DSG3, TNFRSF1B, PI3, C5AR1, and KRT16, as being acne-related through biological verification and text data mining. These findings underscore the potential of AI-driven Q-learning models to revolutionize the study of acne genetics. In conclusion, our Q-learning model offers a promising approach for the selection of acne-related genetic markers, despite minor sensitivity fluctuations. This research highlights the transformative potential of Q-learning in advancing our understanding of the genetics underlying acne, paving the way for more personalized and effective treatments in the future.
AB - Genetic markers for acne are being studied to create personalized treatments based on an individual's genes, and the field is benefiting from the application of artificial intelligence (AI) techniques. One such AI tool, the Q-learning algorithm, is increasingly being utilized by medical researchers to delve into the genetics of acne. In contrast to previous methods, our research introduces a Q-learning model that is adaptable to diverse sample groups. This innovative approach involves preprocessing data by identifying differentially expressed genes and constructing gene-gene connectivity networks. The key advantage of using the Q-learning model lies in its ability to transform acne gene data into Markovian domains, which are essential for selecting relevant genetic markers. Performance evaluations of our Q-learning model have shown high accuracy and specificity, although there may be some sensitivity variations. Notably, this research has identified specific genes, such as CD86, AGPAT3, TMPRSS11D, DSG3, TNFRSF1B, PI3, C5AR1, and KRT16, as being acne-related through biological verification and text data mining. These findings underscore the potential of AI-driven Q-learning models to revolutionize the study of acne genetics. In conclusion, our Q-learning model offers a promising approach for the selection of acne-related genetic markers, despite minor sensitivity fluctuations. This research highlights the transformative potential of Q-learning in advancing our understanding of the genetics underlying acne, paving the way for more personalized and effective treatments in the future.
KW - Acne genetics
KW - Gene expression data
KW - Genetic marker selection
KW - PubMed text data mining
KW - Q-learning
KW - Reinforcement learning
UR - http://www.scopus.com/inward/record.url?scp=85195181158&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85195181158&partnerID=8YFLogxK
U2 - 10.1016/j.eij.2024.100484
DO - 10.1016/j.eij.2024.100484
M3 - Article
AN - SCOPUS:85195181158
SN - 1110-8665
VL - 26
JO - Egyptian Informatics Journal
JF - Egyptian Informatics Journal
M1 - 100484
ER -