TY - JOUR
T1 - Air pollutants and attention deficit hyperactivity disordemedication administration in elementary schools
AU - Saadeh, Rami A.
AU - Jayawardene, Wasantha P.
AU - Lohrmann, David K.
AU - Youssefagha, Ahmed H.
AU - Allouh, Mohammed Z.
N1 - Funding Information:
This study was partly funded by The United Arab Emirates University (grant no. G00003632).
Publisher Copyright:
© 2022, Spandidos Publications. All rights reserved.
PY - 2022/11
Y1 - 2022/11
N2 - Air pollution is considered a risk factor for several diseases, particularly respiratory and cardiovascular diseases. However, the effects of air pollution on neurobe-havioral disorders have not been confirmed as of yet. Thus, the aim of this study was to determine whether there was an association between seven air pollutants and ADHD medica-tion administration (ADHD-MA) in Pennsylvania-located elementary schools over a 3-year period. An ecological study design involving records of 168,825 children from elementary schools in 49 Pennsylvania counties was used. The number of children with ADHD-MA was extracted from an online software specifically designed for allowing nurses to record health conditions in schools. Daily measurements of air pollutants were obtained from the U.S Environmental Protection Agency. The differences in the number of ADHD-MA among the four seasons, for all years, were statistically significant (P<0.001). Three air pollutants (SO2, CO, and PM2.5) were significantly associated with ADHD-MA; no interactions among air pollutants were significant. Air pollution was thus likely associated with ADHD-MA. Prospective epidemiolog-ical and biomedical studies should next examine the molecular relationship between air pollution and ADHD symptoms.
AB - Air pollution is considered a risk factor for several diseases, particularly respiratory and cardiovascular diseases. However, the effects of air pollution on neurobe-havioral disorders have not been confirmed as of yet. Thus, the aim of this study was to determine whether there was an association between seven air pollutants and ADHD medica-tion administration (ADHD-MA) in Pennsylvania-located elementary schools over a 3-year period. An ecological study design involving records of 168,825 children from elementary schools in 49 Pennsylvania counties was used. The number of children with ADHD-MA was extracted from an online software specifically designed for allowing nurses to record health conditions in schools. Daily measurements of air pollutants were obtained from the U.S Environmental Protection Agency. The differences in the number of ADHD-MA among the four seasons, for all years, were statistically significant (P<0.001). Three air pollutants (SO2, CO, and PM2.5) were significantly associated with ADHD-MA; no interactions among air pollutants were significant. Air pollution was thus likely associated with ADHD-MA. Prospective epidemiolog-ical and biomedical studies should next examine the molecular relationship between air pollution and ADHD symptoms.
KW - air pollutants
KW - attention deficit hyperactivity disorder
KW - elementary school
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U2 - 10.3892/br.2022.1568
DO - 10.3892/br.2022.1568
M3 - Article
AN - SCOPUS:85139086474
SN - 2049-9434
VL - 17
JO - Biomedical Reports
JF - Biomedical Reports
IS - 5
M1 - 85
ER -