TY - JOUR
T1 - Alginate/Cucurbit[7]uril/Dequalinium-Based Supramolecular Carbohydrates
T2 - Modulation of FRET Signals by Temperature Control
AU - Sohail, Amir
AU - Alnaqbi, Mohamed A.
AU - Saleh, Na'il
N1 - Funding Information:
The authors thank Professor Panče Naumov from New York University-Abu Dhabi (NYUAD) for encouragement to conduct this work, both Professor Soleiman Hisaindee from UAE University and Professor Vaidhyanathan Ramamurthy from the University of Miami, FL, USA, for technical assistance during the initial preparation of the conjugate, and Reem H. Alzard for her help with the graphics. They also acknowledge the financial support from the UAE University (grant no. ICEER-1-2017) and the NMR measurements (Bruker Corporation, Billerica, MA, USA, 500 MHz) by Dr. Thirumurugan Prakasam from New York University-Abu Dhabi (NYUAD).
Publisher Copyright:
Copyright © 2019 American Chemical Society.
PY - 2019/11/26
Y1 - 2019/11/26
N2 - Herein, we describe the synthesis of a bioactive, inexpensive, and easy-to-handle supramolecular carbohydrate polymer by grafting of cucurbit[7]uril macrocycle (CB7)-encapsulated dequalinium chloride hydrate (DCH) onto alginic acid carbohydrates (ALG) via amide linkage formation and show that light energy transfer based on energy migration can be controlled by altering polymer temperature without changing polymer composition. DCH (donor) and 2-anilinonaphthalene-6-sulfonic acid (acceptor) were used to generate Förster resonance energy transfer (FRET) signals. Stationary and time-resolved photoluminescence spectra of the modified carbohydrate platform revealed that FRET resulted in a color change from violet (∼387 nm) to blue (∼429 nm), which could be repeatedly switched on and off in response to temperature stimuli at 298-368 K. Temperature-dependent NMR measurements suggested that the responsiveness of DCH/CB7ALG to thermal stimuli was due to the threading of CB7 onto the DCH backbone in solution and upon grafting onto ALG polymers.
AB - Herein, we describe the synthesis of a bioactive, inexpensive, and easy-to-handle supramolecular carbohydrate polymer by grafting of cucurbit[7]uril macrocycle (CB7)-encapsulated dequalinium chloride hydrate (DCH) onto alginic acid carbohydrates (ALG) via amide linkage formation and show that light energy transfer based on energy migration can be controlled by altering polymer temperature without changing polymer composition. DCH (donor) and 2-anilinonaphthalene-6-sulfonic acid (acceptor) were used to generate Förster resonance energy transfer (FRET) signals. Stationary and time-resolved photoluminescence spectra of the modified carbohydrate platform revealed that FRET resulted in a color change from violet (∼387 nm) to blue (∼429 nm), which could be repeatedly switched on and off in response to temperature stimuli at 298-368 K. Temperature-dependent NMR measurements suggested that the responsiveness of DCH/CB7ALG to thermal stimuli was due to the threading of CB7 onto the DCH backbone in solution and upon grafting onto ALG polymers.
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U2 - 10.1021/acs.macromol.9b01788
DO - 10.1021/acs.macromol.9b01788
M3 - Article
AN - SCOPUS:85075182485
VL - 52
SP - 9023
EP - 9031
JO - Macromolecules
JF - Macromolecules
SN - 0024-9297
IS - 22
ER -