Alpha-haemolysin, a possible virulence factor in Proteus morganii

L. Emody; S. Voros; T. Pal

doi:10.1016/0378-1097(82)90121-5

Alpha-haemolysin, a possible virulence factor in Proteus morganii

L. Emody, S. Voros, T. Pal

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

In the three animal models described P. morganii strains behaved similarly to E. coli strains studied previously. A marked difference could be observed between the virulence of wild-type haemolytic and nonhaemolytic strains. The rapid appearance of fatal haemorrhagic lung oedema in the lung toxicity assay and the very short survival time in mice infected intraperitoneally with Hly⁺ strains suggest that a toxic effect may be mainly responsible for the enhanced virulence of alpha-haemolysin-producing strains. The parallel loss of alpha-haemolytic capacity and enhanced virulence in actinomycin-D-treated derivatives also supports this idea.

Original language	English
Pages (from-to)	329-331
Number of pages	3
Journal	FEMS Microbiology Letters
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/0378-1097(82)90121-5
Publication status	Published - 1982
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Molecular Biology
Genetics

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title = "Alpha-haemolysin, a possible virulence factor in Proteus morganii",

abstract = "In the three animal models described P. morganii strains behaved similarly to E. coli strains studied previously. A marked difference could be observed between the virulence of wild-type haemolytic and nonhaemolytic strains. The rapid appearance of fatal haemorrhagic lung oedema in the lung toxicity assay and the very short survival time in mice infected intraperitoneally with Hly+ strains suggest that a toxic effect may be mainly responsible for the enhanced virulence of alpha-haemolysin-producing strains. The parallel loss of alpha-haemolytic capacity and enhanced virulence in actinomycin-D-treated derivatives also supports this idea.",

author = "L. Emody and S. Voros and T. Pal",

year = "1982",

doi = "10.1016/0378-1097(82)90121-5",

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journal = "FEMS Microbiology Letters",

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T1 - Alpha-haemolysin, a possible virulence factor in Proteus morganii

AU - Emody, L.

AU - Voros, S.

AU - Pal, T.

PY - 1982

Y1 - 1982

N2 - In the three animal models described P. morganii strains behaved similarly to E. coli strains studied previously. A marked difference could be observed between the virulence of wild-type haemolytic and nonhaemolytic strains. The rapid appearance of fatal haemorrhagic lung oedema in the lung toxicity assay and the very short survival time in mice infected intraperitoneally with Hly+ strains suggest that a toxic effect may be mainly responsible for the enhanced virulence of alpha-haemolysin-producing strains. The parallel loss of alpha-haemolytic capacity and enhanced virulence in actinomycin-D-treated derivatives also supports this idea.

AB - In the three animal models described P. morganii strains behaved similarly to E. coli strains studied previously. A marked difference could be observed between the virulence of wild-type haemolytic and nonhaemolytic strains. The rapid appearance of fatal haemorrhagic lung oedema in the lung toxicity assay and the very short survival time in mice infected intraperitoneally with Hly+ strains suggest that a toxic effect may be mainly responsible for the enhanced virulence of alpha-haemolysin-producing strains. The parallel loss of alpha-haemolytic capacity and enhanced virulence in actinomycin-D-treated derivatives also supports this idea.

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JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

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ER -

Alpha-haemolysin, a possible virulence factor in Proteus morganii

Abstract

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