Abstract
In the three animal models described P. morganii strains behaved similarly to E. coli strains studied previously. A marked difference could be observed between the virulence of wild-type haemolytic and nonhaemolytic strains. The rapid appearance of fatal haemorrhagic lung oedema in the lung toxicity assay and the very short survival time in mice infected intraperitoneally with Hly+ strains suggest that a toxic effect may be mainly responsible for the enhanced virulence of alpha-haemolysin-producing strains. The parallel loss of alpha-haemolytic capacity and enhanced virulence in actinomycin-D-treated derivatives also supports this idea.
| Original language | English |
|---|---|
| Pages (from-to) | 329-331 |
| Number of pages | 3 |
| Journal | FEMS Microbiology Letters |
| Volume | 13 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1982 |
| Externally published | Yes |
ASJC Scopus subject areas
- Microbiology
- Molecular Biology
- Genetics