Alpha-interferon inhibits spontaneous and induced DNA synthesis in hairy cell leukemia

Inaam Bashir Hassan, J. Simon Gronowitz, Mats Carlsson, Christer Sundstrom

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The effect of alpha-interferon (αIFN) on spontaneous or induced proliferation of isolated peripheral blood mononuclear cells from 5 hairy cell leukemia patients was studied. a-IFN inhibited the low spontaneous proliferation of B-1y7 positive hairy cells (HCs) and also the proliferation induced by tumour necrosis factor (TNF). Interleukin-2 did not affect HCs, but induced CD4 positive T cells to proliferate, an effect which αIFN antagonized. The stimulatory effect of TNF on the growth of HCs proved to be reversible and was partially blocked with either anti-TNF receptor or anti-lymphotoxin antibodies. Cellular or secreted thymidine kinase levels reflected the proliferative state of HCs in response to different in vitro treatments, as confirmed by thymidine incorporation and cell cycle studies.

Original languageEnglish
Pages (from-to)69-77
Number of pages9
JournalLeukemia and Lymphoma
Issue number1-2
Publication statusPublished - 1992
Externally publishedYes


  • Deoxythymidine kinase
  • Hairy cell leukemia
  • Interferon
  • Interleukin-2
  • Thymidine incorporation
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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