Abstract
The effect of alpha-interferon (αIFN) on spontaneous or induced proliferation of isolated peripheral blood mononuclear cells from 5 hairy cell leukemia patients was studied. a-IFN inhibited the low spontaneous proliferation of B-1y7 positive hairy cells (HCs) and also the proliferation induced by tumour necrosis factor (TNF). Interleukin-2 did not affect HCs, but induced CD4 positive T cells to proliferate, an effect which αIFN antagonized. The stimulatory effect of TNF on the growth of HCs proved to be reversible and was partially blocked with either anti-TNF receptor or anti-lymphotoxin antibodies. Cellular or secreted thymidine kinase levels reflected the proliferative state of HCs in response to different in vitro treatments, as confirmed by thymidine incorporation and cell cycle studies.
| Original language | English |
|---|---|
| Pages (from-to) | 69-77 |
| Number of pages | 9 |
| Journal | Leukemia and Lymphoma |
| Volume | 7 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 1992 |
| Externally published | Yes |
Keywords
- Deoxythymidine kinase
- Hairy cell leukemia
- Interferon
- Interleukin-2
- Thymidine incorporation
- Tumor necrosis factor
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research
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