Alteration of spinal cord IGF-I receptors and skeletal muscle IGF-I after hind-limb immobilization in the rat

Isam A. Suliman; J. Urban Lindgren; Per Göran Gillberg; Adlan M. Elhassan; Christine Monneron; Abdu Adem

doi:10.1097/00001756-199904260-00007

Alteration of spinal cord IGF-I receptors and skeletal muscle IGF-I after hind-limb immobilization in the rat

Isam A. Suliman, J. Urban Lindgren, Per Göran Gillberg, Adlan M. Elhassan, Christine Monneron, Abdu Adem

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

THE effects of 4 weeks' hind-limb immobilization on the spinal cord insulin-like growth factor-I (IGF-I) receptors and skeletal muscle IGF-I level was investigated in rats. Quantitative receptor autoradiography using [¹²⁵I]IGF-I as a ligand was performed to measure IGF-I receptors in cryosections from the lumbar region of the spinal cord. IGF-I receptor levels were significantly higher in all spinal cord laminae on the side ipsilateral to the immobilized limb than in the same spinal level of the controls. Using radioimmunoassay (RIA), IGF-I levels were significantly low in the soleus (SOL), but not the tibialis anterior (TIB) muscles, compared to the controls. The enhancement of the spinal cord IGF-I receptors after hind-limb immobilization may constitute part of the nervous system response to disuse.

Original language	English
Pages (from-to)	1195-1199
Number of pages	5
Journal	NeuroReport
Volume	10
Issue number	6
DOIs	https://doi.org/10.1097/00001756-199904260-00007
Publication status	Published - Apr 26 1999
Externally published	Yes

Keywords

Autoradiography
IGF-I receptors
Immobilization
Skeletal muscle
Spinal cord

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1097/00001756-199904260-00007

Cite this

@article{2bfd89f543c6410b81b84f6172f7ada9,

title = "Alteration of spinal cord IGF-I receptors and skeletal muscle IGF-I after hind-limb immobilization in the rat",

abstract = "THE effects of 4 weeks' hind-limb immobilization on the spinal cord insulin-like growth factor-I (IGF-I) receptors and skeletal muscle IGF-I level was investigated in rats. Quantitative receptor autoradiography using [125I]IGF-I as a ligand was performed to measure IGF-I receptors in cryosections from the lumbar region of the spinal cord. IGF-I receptor levels were significantly higher in all spinal cord laminae on the side ipsilateral to the immobilized limb than in the same spinal level of the controls. Using radioimmunoassay (RIA), IGF-I levels were significantly low in the soleus (SOL), but not the tibialis anterior (TIB) muscles, compared to the controls. The enhancement of the spinal cord IGF-I receptors after hind-limb immobilization may constitute part of the nervous system response to disuse.",

keywords = "Autoradiography, IGF-I receptors, Immobilization, Skeletal muscle, Spinal cord",

author = "Suliman, {Isam A.} and Lindgren, {J. Urban} and Gillberg, {Per G{\"o}ran} and Elhassan, {Adlan M.} and Christine Monneron and Abdu Adem",

year = "1999",

month = apr,

day = "26",

doi = "10.1097/00001756-199904260-00007",

language = "English",

volume = "10",

pages = "1195--1199",

journal = "NeuroReport",

issn = "0959-4965",

publisher = "Lippincott Williams and Wilkins",

number = "6",

}

TY - JOUR

T1 - Alteration of spinal cord IGF-I receptors and skeletal muscle IGF-I after hind-limb immobilization in the rat

AU - Suliman, Isam A.

AU - Lindgren, J. Urban

AU - Gillberg, Per Göran

AU - Elhassan, Adlan M.

AU - Monneron, Christine

AU - Adem, Abdu

PY - 1999/4/26

Y1 - 1999/4/26

N2 - THE effects of 4 weeks' hind-limb immobilization on the spinal cord insulin-like growth factor-I (IGF-I) receptors and skeletal muscle IGF-I level was investigated in rats. Quantitative receptor autoradiography using [125I]IGF-I as a ligand was performed to measure IGF-I receptors in cryosections from the lumbar region of the spinal cord. IGF-I receptor levels were significantly higher in all spinal cord laminae on the side ipsilateral to the immobilized limb than in the same spinal level of the controls. Using radioimmunoassay (RIA), IGF-I levels were significantly low in the soleus (SOL), but not the tibialis anterior (TIB) muscles, compared to the controls. The enhancement of the spinal cord IGF-I receptors after hind-limb immobilization may constitute part of the nervous system response to disuse.

AB - THE effects of 4 weeks' hind-limb immobilization on the spinal cord insulin-like growth factor-I (IGF-I) receptors and skeletal muscle IGF-I level was investigated in rats. Quantitative receptor autoradiography using [125I]IGF-I as a ligand was performed to measure IGF-I receptors in cryosections from the lumbar region of the spinal cord. IGF-I receptor levels were significantly higher in all spinal cord laminae on the side ipsilateral to the immobilized limb than in the same spinal level of the controls. Using radioimmunoassay (RIA), IGF-I levels were significantly low in the soleus (SOL), but not the tibialis anterior (TIB) muscles, compared to the controls. The enhancement of the spinal cord IGF-I receptors after hind-limb immobilization may constitute part of the nervous system response to disuse.

KW - Autoradiography

KW - IGF-I receptors

KW - Immobilization

KW - Skeletal muscle

KW - Spinal cord

UR - http://www.scopus.com/inward/record.url?scp=0033606065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033606065&partnerID=8YFLogxK

U2 - 10.1097/00001756-199904260-00007

DO - 10.1097/00001756-199904260-00007

M3 - Article

C2 - 10363923

AN - SCOPUS:0033606065

SN - 0959-4965

VL - 10

SP - 1195

EP - 1199

JO - NeuroReport

JF - NeuroReport

IS - 6

ER -

Alteration of spinal cord IGF-I receptors and skeletal muscle IGF-I after hind-limb immobilization in the rat

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this