Alterations in information transmission in ensembles of primary muscle spindle afferents after muscle fatigue in heteronymous muscle

J. Pedersen, M. Ljubisavljevic, M. Bergenheim, H. Johansson

Research output: Contribution to journalArticlepeer-review

94 Citations (Scopus)

Abstract

This study showed that fatigue of the ipsilateral medial gastrocnemius muscle caused a clear-cut reduction in the ability of ensembles of primary muscle spindle afferents from the lateral gastrocnemius muscle to discriminate between muscle stretches of varying amplitude. The results were probably caused by reflex-mediated effects from chemosensitive group III and IV afferents onto the γ-motoneurons projecting to lateral gastrocnemius muscle spindles. The experiments were conducted on seven cats anaesthetized with α-chloralose and a total of 41 primary muscle spindle afferents from the lateral gastrocnemius were registered. Afferents were simultaneously recorded in ensembles of three to 10 afferents. A method based on principal component analysis and algorithms for quantification of stimulus discrimination in ensembles of muscle afferents was used prior to, immediately following and five or more minutes after muscle fatigue had been induced to the ipsilateral medial gastrocnemius muscle. It is well established that the primary muscle spindle afferents play an important role in proprioception and kinaesthesia. Therefore the decrease in the accuracy of the information transmitted by ensembles of primary muscle spindle afferents caused by fatigue in an ipsilateral muscle implies concomitant effects on proprioception and kinaesthesia.

Original languageEnglish
Pages (from-to)953-959
Number of pages7
JournalNeuroscience
Volume84
Issue number3
DOIs
Publication statusPublished - Feb 24 1998
Externally publishedYes

Keywords

  • Afferent
  • Ensemble coding
  • Fusimotor neuron
  • Muscle fatigue
  • Simultaneous recording
  • Stimulus discrimination

ASJC Scopus subject areas

  • General Neuroscience

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