TY - JOUR
T1 - Amino acid sequence of a snake venom toxin that binds to the muscarinic acetylcholine receptor
AU - Karlsson, Evert
AU - Risinger, Carl
AU - Jolkkonen, Mikael
AU - Wernstedt, Christer
AU - Adem, Abdu
N1 - Funding Information:
Acknowledgements-This work was supported by the Swedish Natural Science Research Council and by O.E. and Edla Johanssons StiRelse . The analyses performed by the Amino Acid Analysis Laboratory at the Department of Biochemistry are gratefully acknowledged . We thank ANEZ-rE AsrRBM for help with the isolation of toxins .
PY - 1991
Y1 - 1991
N2 - E. Karlsson, C. Risinger, M. Jolkkonen, C. Wernstedt and A. Adem. Amino acid sequence of a snake venom toxin that binds to the muscarinic acetylcholine receptor. Toxicon 29, 521-526, 1991.-The green mamba, Dendroaspis angusticeps, has two protein toxins that bind to the muscarinic acetylcholine receptor. The sequence of muscarinic toxin 2 was determined with an automatic gas phase sequencer. The C-terminal residue is Asp as determined by hydrazinolysis and amino acid analysis. Toxin 2 has 65 amino acid residues and a formula weight of 7040. It is homologous to a large number of other snake venom toxins as short α-neurotoxins, cardiotoxins/cytotoxins and angusticeps-type toxins of mamba venoms. The sequence is confirmed in the accompanying article (Ducancel, F., Rowan, E. G., Cassart, E., Harvey, A. L., Menez, A. and Boulain, J.-C. Toxicon 29, 516-520, 1991).
AB - E. Karlsson, C. Risinger, M. Jolkkonen, C. Wernstedt and A. Adem. Amino acid sequence of a snake venom toxin that binds to the muscarinic acetylcholine receptor. Toxicon 29, 521-526, 1991.-The green mamba, Dendroaspis angusticeps, has two protein toxins that bind to the muscarinic acetylcholine receptor. The sequence of muscarinic toxin 2 was determined with an automatic gas phase sequencer. The C-terminal residue is Asp as determined by hydrazinolysis and amino acid analysis. Toxin 2 has 65 amino acid residues and a formula weight of 7040. It is homologous to a large number of other snake venom toxins as short α-neurotoxins, cardiotoxins/cytotoxins and angusticeps-type toxins of mamba venoms. The sequence is confirmed in the accompanying article (Ducancel, F., Rowan, E. G., Cassart, E., Harvey, A. L., Menez, A. and Boulain, J.-C. Toxicon 29, 516-520, 1991).
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U2 - 10.1016/0041-0101(91)90027-O
DO - 10.1016/0041-0101(91)90027-O
M3 - Article
C2 - 1862525
AN - SCOPUS:0026021093
SN - 0041-0101
VL - 29
SP - 521
EP - 526
JO - Toxicon
JF - Toxicon
IS - 4-5
ER -