Amino acid sequence of a snake venom toxin that binds to the muscarinic acetylcholine receptor

Evert Karlsson; Carl Risinger; Mikael Jolkkonen; Christer Wernstedt; Abdu Adem

doi:10.1016/0041-0101(91)90027-O

Amino acid sequence of a snake venom toxin that binds to the muscarinic acetylcholine receptor

Evert Karlsson
, Carl Risinger
, Mikael Jolkkonen
, Christer Wernstedt
, Abdu Adem

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

E. Karlsson, C. Risinger, M. Jolkkonen, C. Wernstedt and A. Adem. Amino acid sequence of a snake venom toxin that binds to the muscarinic acetylcholine receptor. Toxicon 29, 521-526, 1991.-The green mamba, Dendroaspis angusticeps, has two protein toxins that bind to the muscarinic acetylcholine receptor. The sequence of muscarinic toxin 2 was determined with an automatic gas phase sequencer. The C-terminal residue is Asp as determined by hydrazinolysis and amino acid analysis. Toxin 2 has 65 amino acid residues and a formula weight of 7040. It is homologous to a large number of other snake venom toxins as short α-neurotoxins, cardiotoxins/cytotoxins and angusticeps-type toxins of mamba venoms. The sequence is confirmed in the accompanying article (Ducancel, F., Rowan, E. G., Cassart, E., Harvey, A. L., Menez, A. and Boulain, J.-C. Toxicon 29, 516-520, 1991).

Original language	English
Pages (from-to)	521-526
Number of pages	6
Journal	Toxicon
Volume	29
Issue number	4-5
DOIs	https://doi.org/10.1016/0041-0101(91)90027-O
Publication status	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Toxicology

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10.1016/0041-0101(91)90027-O

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title = "Amino acid sequence of a snake venom toxin that binds to the muscarinic acetylcholine receptor",

abstract = "E. Karlsson, C. Risinger, M. Jolkkonen, C. Wernstedt and A. Adem. Amino acid sequence of a snake venom toxin that binds to the muscarinic acetylcholine receptor. Toxicon 29, 521-526, 1991.-The green mamba, Dendroaspis angusticeps, has two protein toxins that bind to the muscarinic acetylcholine receptor. The sequence of muscarinic toxin 2 was determined with an automatic gas phase sequencer. The C-terminal residue is Asp as determined by hydrazinolysis and amino acid analysis. Toxin 2 has 65 amino acid residues and a formula weight of 7040. It is homologous to a large number of other snake venom toxins as short α-neurotoxins, cardiotoxins/cytotoxins and angusticeps-type toxins of mamba venoms. The sequence is confirmed in the accompanying article (Ducancel, F., Rowan, E. G., Cassart, E., Harvey, A. L., Menez, A. and Boulain, J.-C. Toxicon 29, 516-520, 1991).",

author = "Evert Karlsson and Carl Risinger and Mikael Jolkkonen and Christer Wernstedt and Abdu Adem",

note = "Funding Information: Acknowledgements-This work was supported by the Swedish Natural Science Research Council and by O.E. and Edla Johanssons StiRelse . The analyses performed by the Amino Acid Analysis Laboratory at the Department of Biochemistry are gratefully acknowledged . We thank ANEZ-rE AsrRBM for help with the isolation of toxins .",

year = "1991",

doi = "10.1016/0041-0101(91)90027-O",

language = "English",

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AU - Jolkkonen, Mikael

AU - Wernstedt, Christer

AU - Adem, Abdu

N1 - Funding Information: Acknowledgements-This work was supported by the Swedish Natural Science Research Council and by O.E. and Edla Johanssons StiRelse . The analyses performed by the Amino Acid Analysis Laboratory at the Department of Biochemistry are gratefully acknowledged . We thank ANEZ-rE AsrRBM for help with the isolation of toxins .

PY - 1991

Y1 - 1991

N2 - E. Karlsson, C. Risinger, M. Jolkkonen, C. Wernstedt and A. Adem. Amino acid sequence of a snake venom toxin that binds to the muscarinic acetylcholine receptor. Toxicon 29, 521-526, 1991.-The green mamba, Dendroaspis angusticeps, has two protein toxins that bind to the muscarinic acetylcholine receptor. The sequence of muscarinic toxin 2 was determined with an automatic gas phase sequencer. The C-terminal residue is Asp as determined by hydrazinolysis and amino acid analysis. Toxin 2 has 65 amino acid residues and a formula weight of 7040. It is homologous to a large number of other snake venom toxins as short α-neurotoxins, cardiotoxins/cytotoxins and angusticeps-type toxins of mamba venoms. The sequence is confirmed in the accompanying article (Ducancel, F., Rowan, E. G., Cassart, E., Harvey, A. L., Menez, A. and Boulain, J.-C. Toxicon 29, 516-520, 1991).

AB - E. Karlsson, C. Risinger, M. Jolkkonen, C. Wernstedt and A. Adem. Amino acid sequence of a snake venom toxin that binds to the muscarinic acetylcholine receptor. Toxicon 29, 521-526, 1991.-The green mamba, Dendroaspis angusticeps, has two protein toxins that bind to the muscarinic acetylcholine receptor. The sequence of muscarinic toxin 2 was determined with an automatic gas phase sequencer. The C-terminal residue is Asp as determined by hydrazinolysis and amino acid analysis. Toxin 2 has 65 amino acid residues and a formula weight of 7040. It is homologous to a large number of other snake venom toxins as short α-neurotoxins, cardiotoxins/cytotoxins and angusticeps-type toxins of mamba venoms. The sequence is confirmed in the accompanying article (Ducancel, F., Rowan, E. G., Cassart, E., Harvey, A. L., Menez, A. and Boulain, J.-C. Toxicon 29, 516-520, 1991).

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ER -

Amino acid sequence of a snake venom toxin that binds to the muscarinic acetylcholine receptor

Abstract

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