TY - JOUR
T1 - Ammi Visnaga in treatment of urolithiasis and hypertriglyceridemia
AU - Bhagavathula, Akshaya Srikanth
AU - Al-Khatib, Ahed Jumah Mahmoud
AU - Elnour, Asim Ahmed
AU - Al Kalbani, Naama M.S.
AU - Shehab, Abdulla
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Ammi visnaga is a widely distributed Ancient Egyptian medicinal plant used for treatment of several diseases including urolithiasis (kidney stones). The active chemical constituents' khellin and visnagin obtained from the A. visnaga seeds have activity of antilithiogenic and pleiotropic. However, little is known about its activity on hypertriglyceridemia. The main aim of this review is to explore the use of A. visnaga in urolithiasis and to present a case of relevancy. We highlighted a case of a patient who has recurrent urethral stones and hypertriglyceridemia. The patient was treated with A. visnaga seeds, has recovered completely from ureteral stones and his high-density lipoprotein (HDL)-cholesterol low levels retained to normal after using of A. visnaga seeds for 10 days. The present case of A. visnaga seeds being local medicinal plant has shown the effect in treating urolithiasis with extended effect on raising HDL-cholesterol. These results may provide insights for in vitro studies for isolation of these biologically active compounds for potential in raising HDL-cholesterol. Whether or not the later effect can have clinical utility remains to be explored.
AB - Ammi visnaga is a widely distributed Ancient Egyptian medicinal plant used for treatment of several diseases including urolithiasis (kidney stones). The active chemical constituents' khellin and visnagin obtained from the A. visnaga seeds have activity of antilithiogenic and pleiotropic. However, little is known about its activity on hypertriglyceridemia. The main aim of this review is to explore the use of A. visnaga in urolithiasis and to present a case of relevancy. We highlighted a case of a patient who has recurrent urethral stones and hypertriglyceridemia. The patient was treated with A. visnaga seeds, has recovered completely from ureteral stones and his high-density lipoprotein (HDL)-cholesterol low levels retained to normal after using of A. visnaga seeds for 10 days. The present case of A. visnaga seeds being local medicinal plant has shown the effect in treating urolithiasis with extended effect on raising HDL-cholesterol. These results may provide insights for in vitro studies for isolation of these biologically active compounds for potential in raising HDL-cholesterol. Whether or not the later effect can have clinical utility remains to be explored.
KW - Ammi visnaga
KW - high-density lipoprotein
KW - khellin
KW - ureteral stones
KW - urolithiasis
KW - visnagin
UR - http://www.scopus.com/inward/record.url?scp=84945979804&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84945979804&partnerID=8YFLogxK
U2 - 10.4103/0974-8490.167894
DO - 10.4103/0974-8490.167894
M3 - Article
AN - SCOPUS:84945979804
SN - 0974-8490
VL - 7
SP - 397
EP - 400
JO - Pharmacognosy Research
JF - Pharmacognosy Research
IS - 4
ER -