An increase in mucosal insulin-like growth factor II content in postresectional rat intestine suggests autocrine or paracrine growth stimulation

M. Wirén, T. E. Adrian, U. Arnelo, J. Permert, P. Staab, J. Larsson

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Background: Luminal nutrients and growth factors regulate postresectional intestinal growth. The interplay between glutamine and regulatory gastrointestinal peptides is not known. Methods: The effects of intestinal resection on tissue and plasma concentrations of peptides were studied in 60 Sprague-Dawley rats divided into resected, transected, or unoperated groups. Subgroups were fed either a glutamine-free or a glutamine- supplemented diet for 7 days. Epidermal growth factor, transforming growth factor-α, insulin-like growth factors (IGF) I and II, peptide YY (PYY), and enteroglucagon were analyzed in intestinal mucosa and in portal plasma by radioimmunoassay. Results: No glutamine-specific effects were seen. The mucosal content of IGF-II (P < 0.01) and the portal levels of enteroglucagon and PYY (P < 0.05-0.01) increased after intestinal resection. Conclusions: The increase in PYY and enteroglucagon in portal blood supports a hormonal role in the postresectional adaptation. The increase in IGF II in the ileal mucosa, without changes in plasma, implies autocrine or paracrine growth stimulation at this stage after resection.

Original languageEnglish
Pages (from-to)1080-1086
Number of pages7
JournalScandinavian Journal of Gastroenterology
Volume33
Issue number10
DOIs
Publication statusPublished - 1998
Externally publishedYes

Keywords

  • Enteroglucagon
  • Glutamine
  • Insulin-like growth factor II
  • Intestinal resection
  • Peptide YY

ASJC Scopus subject areas

  • Gastroenterology

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