Abstract
The guest-host interaction between Dapsone drug and β-cyclodextrin (β-CD) was investigated using fluorescence spectroscopy, 1H-NMR, and liquid chromatography with fluorescence detection. The optimized conditions for the interaction were investigated by spectrofluorometry and were found to be at 0.2 mg/mL (0.176 mM) of β-CD and pH 8.8. For these conditions, very low concentration of Dapsone drug of 2.4 ng/mL (12.97 nM) can be detected. The standard addition method was utilized to detect Dapsone in influent and effluent wastewater samples in the sub parts per billion concentration range by HPLC-FLD using β-CD as an additive in the mobile phase.
Original language | English |
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Pages (from-to) | 242-247 |
Number of pages | 6 |
Journal | World Journal of Chemical Education |
Volume | 7 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2019 |
Keywords
- dapsone
- fluorescence
- guest-host interaction
- wastewater
- β-cyclodextrin
ASJC Scopus subject areas
- Analytical Chemistry
- Chemistry (miscellaneous)
- Education
- Physical and Theoretical Chemistry