An Undergraduate Experiment Using Cyclodextrin - Assisted Sensitive Fluorescence Detection and Quantitation of Dapsone Drug in Wastewater Samples

Mohammed A. Meetani, Ahmad Alhalabi, Mohammed K. Al-Tabaji, Noor I. Albadawi, Nada Elmari, Soleiman Hisaindee, Abdullah Al-Hemyari, Munjed Maraqa

Research output: Contribution to journalArticlepeer-review

Abstract

The guest-host interaction between Dapsone drug and β-cyclodextrin (β-CD) was investigated using fluorescence spectroscopy, 1H-NMR, and liquid chromatography with fluorescence detection. The optimized conditions for the interaction were investigated by spectrofluorometry and were found to be at 0.2 mg/mL (0.176 mM) of β-CD and pH 8.8. For these conditions, very low concentration of Dapsone drug of 2.4 ng/mL (12.97 nM) can be detected. The standard addition method was utilized to detect Dapsone in influent and effluent wastewater samples in the sub parts per billion concentration range by HPLC-FLD using β-CD as an additive in the mobile phase.

Original languageEnglish
Pages (from-to)242-247
Number of pages6
JournalWorld Journal of Chemical Education
Volume7
Issue number4
DOIs
Publication statusPublished - 2019

Keywords

  • dapsone
  • fluorescence
  • guest-host interaction
  • wastewater
  • β-cyclodextrin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Education
  • Physical and Theoretical Chemistry

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