An Undergraduate Experiment Using Cyclodextrin - Assisted Sensitive Fluorescence Detection and Quantitation of Dapsone Drug in Wastewater Samples

Mohammed A. Meetani; Ahmad Alhalabi; Mohammed K. Al-Tabaji; Noor I. Albadawi; Nada Elmari; Soleiman Hisaindee; Abdullah Al-Hemyari; Munjed Maraqa

doi:10.12691/wjce-7-4-2

An Undergraduate Experiment Using Cyclodextrin - Assisted Sensitive Fluorescence Detection and Quantitation of Dapsone Drug in Wastewater Samples

Mohammed A. Meetani, Ahmad Alhalabi, Mohammed K. Al-Tabaji, Noor I. Albadawi, Nada Elmari, Soleiman Hisaindee, Abdullah Al-Hemyari, Munjed Maraqa

Research output: Contribution to journal › Article › peer-review

Abstract

The guest-host interaction between Dapsone drug and β-cyclodextrin (β-CD) was investigated using fluorescence spectroscopy, ¹H-NMR, and liquid chromatography with fluorescence detection. The optimized conditions for the interaction were investigated by spectrofluorometry and were found to be at 0.2 mg/mL (0.176 mM) of β-CD and pH 8.8. For these conditions, very low concentration of Dapsone drug of 2.4 ng/mL (12.97 nM) can be detected. The standard addition method was utilized to detect Dapsone in influent and effluent wastewater samples in the sub parts per billion concentration range by HPLC-FLD using β-CD as an additive in the mobile phase.

Original language	English
Pages (from-to)	242-247
Number of pages	6
Journal	World Journal of Chemical Education
Volume	7
Issue number	4
DOIs	https://doi.org/10.12691/wjce-7-4-2
Publication status	Published - 2019

Keywords

dapsone
fluorescence
guest-host interaction
wastewater
β-cyclodextrin

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Education
Physical and Theoretical Chemistry

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10.12691/wjce-7-4-2

Cite this

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title = "An Undergraduate Experiment Using Cyclodextrin - Assisted Sensitive Fluorescence Detection and Quantitation of Dapsone Drug in Wastewater Samples",

abstract = "The guest-host interaction between Dapsone drug and β-cyclodextrin (β-CD) was investigated using fluorescence spectroscopy, 1H-NMR, and liquid chromatography with fluorescence detection. The optimized conditions for the interaction were investigated by spectrofluorometry and were found to be at 0.2 mg/mL (0.176 mM) of β-CD and pH 8.8. For these conditions, very low concentration of Dapsone drug of 2.4 ng/mL (12.97 nM) can be detected. The standard addition method was utilized to detect Dapsone in influent and effluent wastewater samples in the sub parts per billion concentration range by HPLC-FLD using β-CD as an additive in the mobile phase.",

keywords = "dapsone, fluorescence, guest-host interaction, wastewater, β-cyclodextrin",

author = "Meetani, {Mohammed A.} and Ahmad Alhalabi and Al-Tabaji, {Mohammed K.} and Albadawi, {Noor I.} and Nada Elmari and Soleiman Hisaindee and Abdullah Al-Hemyari and Munjed Maraqa",

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doi = "10.12691/wjce-7-4-2",

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T1 - An Undergraduate Experiment Using Cyclodextrin - Assisted Sensitive Fluorescence Detection and Quantitation of Dapsone Drug in Wastewater Samples

AU - Meetani, Mohammed A.

AU - Alhalabi, Ahmad

AU - Al-Tabaji, Mohammed K.

AU - Albadawi, Noor I.

AU - Elmari, Nada

AU - Hisaindee, Soleiman

AU - Al-Hemyari, Abdullah

AU - Maraqa, Munjed

N1 - Publisher Copyright: © The Author(s) 2019

PY - 2019

Y1 - 2019

N2 - The guest-host interaction between Dapsone drug and β-cyclodextrin (β-CD) was investigated using fluorescence spectroscopy, 1H-NMR, and liquid chromatography with fluorescence detection. The optimized conditions for the interaction were investigated by spectrofluorometry and were found to be at 0.2 mg/mL (0.176 mM) of β-CD and pH 8.8. For these conditions, very low concentration of Dapsone drug of 2.4 ng/mL (12.97 nM) can be detected. The standard addition method was utilized to detect Dapsone in influent and effluent wastewater samples in the sub parts per billion concentration range by HPLC-FLD using β-CD as an additive in the mobile phase.

AB - The guest-host interaction between Dapsone drug and β-cyclodextrin (β-CD) was investigated using fluorescence spectroscopy, 1H-NMR, and liquid chromatography with fluorescence detection. The optimized conditions for the interaction were investigated by spectrofluorometry and were found to be at 0.2 mg/mL (0.176 mM) of β-CD and pH 8.8. For these conditions, very low concentration of Dapsone drug of 2.4 ng/mL (12.97 nM) can be detected. The standard addition method was utilized to detect Dapsone in influent and effluent wastewater samples in the sub parts per billion concentration range by HPLC-FLD using β-CD as an additive in the mobile phase.

KW - dapsone

KW - fluorescence

KW - guest-host interaction

KW - wastewater

KW - β-cyclodextrin

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VL - 7

SP - 242

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JO - World Journal of Chemical Education

JF - World Journal of Chemical Education

IS - 4

ER -

An Undergraduate Experiment Using Cyclodextrin - Assisted Sensitive Fluorescence Detection and Quantitation of Dapsone Drug in Wastewater Samples

Abstract

Keywords

ASJC Scopus subject areas

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