Analytical solution to the simultaneous Michaelis-Menten and second-order kinetics problem

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2 Citations (Scopus)

Abstract

An analytic solution is presented for the simultaneous substrate elimination problem that combines Michaelis-Menten (MM) consumption with an irreversible homo-dimerization process. The implicit solution involves logarithm and inverse tangent functions and perfectly agrees with the numerical solution of the differential equation. A solution is also presented for the generalized dynamical problem that simultaneously combines MM kinetics with first and second-order processes. The exact expressions for the half-life and the area under the curve are also presented for these problems.

Original languageEnglish
Pages (from-to)2539-2560
Number of pages22
JournalReaction Kinetics, Mechanisms and Catalysis
Volume137
Issue number5
DOIs
Publication statusPublished - Oct 2024

Keywords

  • Dimerization
  • Enzyme kinetics
  • Half-life
  • Michaelis-Menten (MM)
  • Second-order kinetics

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry

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