Ancient Xinjiang mitogenomes reveal intense admixture with high genetic diversity

Wenjun Wang; Manyu Ding; Jacob D. Gardner; Yongqiang Wang; Bo Miao; Wu Guo; Xinhua Wu; Qiurong Ruan; Jianjun Yu; Xingjun Hu; Bo Wang; Xiaohong Wu; Zihua Tang; Alipujiang Niyazi; Jie Zhang; Xien Chang; Yunpeng Tang; Meng Ren; Peng Cao; Feng Liu; Qingyan Dai; Xiaotian Feng; Ruowei Yang; Ming Zhang; Tianyi Wang; Wanjing Ping; Weihong Hou; Wenying Li; Jian Ma; Vikas Kumar; Qiaomei Fu

doi:10.1126/sciadv.abd6690

Ancient Xinjiang mitogenomes reveal intense admixture with high genetic diversity

Wenjun Wang
, Manyu Ding
, Jacob D. Gardner
, Yongqiang Wang
, Bo Miao
, Wu Guo
, Xinhua Wu
, Qiurong Ruan
, Jianjun Yu
, Xingjun Hu
, Bo Wang
, Xiaohong Wu
, Zihua Tang
, Alipujiang Niyazi
, Jie Zhang
, Xien Chang
, Yunpeng Tang
, Meng Ren
, Peng Cao
, Feng Liu

Qingyan Dai, Xiaotian Feng, Ruowei Yang, Ming Zhang, Tianyi Wang, Wanjing Ping, Weihong Hou, Wenying Li, Jian Ma, Vikas Kumar, Qiaomei Fu

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Xinjiang is a key region in northwestern China, connecting East and West Eurasian populations and cultures for thousands of years. To understand the genetic history of Xinjiang, we sequenced 237 complete ancient human mitochondrial genomes from the Bronze Age through Historical Era (41 archaeological sites). Overall, the Bronze Age Xinjiang populations show high diversity and regional genetic affinities with Steppe and northeastern Asian populations along with a deep ancient Siberian connection for the Tarim Basin Xiaohe individuals. In the Iron Age, in general, Steppe-related and northeastern Asian admixture intensified, with North and East Xinjiang populations showing more affinity with northeastern Asians and South Xinjiang populations showing more affinity with Central Asians. The genetic structure observed in the Historical Era of Xinjiang is similar to that in the Iron Age, demonstrating genetic continuity since the Iron Age with some additional genetic admixture with populations surrounding the Xinjiang region.

Original language	English
Article number	eabd6690
Journal	Science advances
Volume	7
Issue number	14
DOIs	https://doi.org/10.1126/sciadv.abd6690
Publication status	Published - Mar 2021
Externally published	Yes

ASJC Scopus subject areas

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Wang, W., Ding, M., Gardner, J. D., Wang, Y., Miao, B., Guo, W., Wu, X., Ruan, Q., Yu, J., Hu, X., Wang, B., Wu, X., Tang, Z., Niyazi, A., Zhang, J., Chang, X., Tang, Y., Ren, M., Cao, P., ... Fu, Q. (2021). Ancient Xinjiang mitogenomes reveal intense admixture with high genetic diversity. Science advances, 7(14), Article eabd6690. https://doi.org/10.1126/sciadv.abd6690

Wang, W, Ding, M, Gardner, JD, Wang, Y, Miao, B, Guo, W, Wu, X, Ruan, Q, Yu, J, Hu, X, Wang, B, Wu, X, Tang, Z, Niyazi, A, Zhang, J, Chang, X, Tang, Y, Ren, M, Cao, P, Liu, F, Dai, Q, Feng, X, Yang, R, Zhang, M, Wang, T, Ping, W, Hou, W, Li, W, Ma, J, Kumar, V & Fu, Q 2021, 'Ancient Xinjiang mitogenomes reveal intense admixture with high genetic diversity', Science advances, vol. 7, no. 14, eabd6690. https://doi.org/10.1126/sciadv.abd6690

@article{ecdf839676584dad9df11b341f1ba455,

title = "Ancient Xinjiang mitogenomes reveal intense admixture with high genetic diversity",

abstract = "Xinjiang is a key region in northwestern China, connecting East and West Eurasian populations and cultures for thousands of years. To understand the genetic history of Xinjiang, we sequenced 237 complete ancient human mitochondrial genomes from the Bronze Age through Historical Era (41 archaeological sites). Overall, the Bronze Age Xinjiang populations show high diversity and regional genetic affinities with Steppe and northeastern Asian populations along with a deep ancient Siberian connection for the Tarim Basin Xiaohe individuals. In the Iron Age, in general, Steppe-related and northeastern Asian admixture intensified, with North and East Xinjiang populations showing more affinity with northeastern Asians and South Xinjiang populations showing more affinity with Central Asians. The genetic structure observed in the Historical Era of Xinjiang is similar to that in the Iron Age, demonstrating genetic continuity since the Iron Age with some additional genetic admixture with populations surrounding the Xinjiang region.",

author = "Wenjun Wang and Manyu Ding and Gardner, \{Jacob D.\} and Yongqiang Wang and Bo Miao and Wu Guo and Xinhua Wu and Qiurong Ruan and Jianjun Yu and Xingjun Hu and Bo Wang and Xiaohong Wu and Zihua Tang and Alipujiang Niyazi and Jie Zhang and Xien Chang and Yunpeng Tang and Meng Ren and Peng Cao and Feng Liu and Qingyan Dai and Xiaotian Feng and Ruowei Yang and Ming Zhang and Tianyi Wang and Wanjing Ping and Weihong Hou and Wenying Li and Jian Ma and Vikas Kumar and Qiaomei Fu",

note = "Publisher Copyright: Copyright {\textcopyright} 2021 The Authors, some rights reserved.",

year = "2021",

month = mar,

doi = "10.1126/sciadv.abd6690",

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journal = "Science advances",

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AU - Wang, Wenjun

AU - Ding, Manyu

AU - Gardner, Jacob D.

AU - Wang, Yongqiang

AU - Miao, Bo

AU - Guo, Wu

AU - Wu, Xinhua

AU - Ruan, Qiurong

AU - Yu, Jianjun

AU - Hu, Xingjun

AU - Wang, Bo

AU - Wu, Xiaohong

AU - Tang, Zihua

AU - Niyazi, Alipujiang

AU - Zhang, Jie

AU - Chang, Xien

AU - Tang, Yunpeng

AU - Ren, Meng

AU - Cao, Peng

AU - Liu, Feng

AU - Dai, Qingyan

AU - Feng, Xiaotian

AU - Yang, Ruowei

AU - Zhang, Ming

AU - Wang, Tianyi

AU - Ping, Wanjing

AU - Hou, Weihong

AU - Li, Wenying

AU - Ma, Jian

AU - Kumar, Vikas

AU - Fu, Qiaomei

PY - 2021/3

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N2 - Xinjiang is a key region in northwestern China, connecting East and West Eurasian populations and cultures for thousands of years. To understand the genetic history of Xinjiang, we sequenced 237 complete ancient human mitochondrial genomes from the Bronze Age through Historical Era (41 archaeological sites). Overall, the Bronze Age Xinjiang populations show high diversity and regional genetic affinities with Steppe and northeastern Asian populations along with a deep ancient Siberian connection for the Tarim Basin Xiaohe individuals. In the Iron Age, in general, Steppe-related and northeastern Asian admixture intensified, with North and East Xinjiang populations showing more affinity with northeastern Asians and South Xinjiang populations showing more affinity with Central Asians. The genetic structure observed in the Historical Era of Xinjiang is similar to that in the Iron Age, demonstrating genetic continuity since the Iron Age with some additional genetic admixture with populations surrounding the Xinjiang region.

AB - Xinjiang is a key region in northwestern China, connecting East and West Eurasian populations and cultures for thousands of years. To understand the genetic history of Xinjiang, we sequenced 237 complete ancient human mitochondrial genomes from the Bronze Age through Historical Era (41 archaeological sites). Overall, the Bronze Age Xinjiang populations show high diversity and regional genetic affinities with Steppe and northeastern Asian populations along with a deep ancient Siberian connection for the Tarim Basin Xiaohe individuals. In the Iron Age, in general, Steppe-related and northeastern Asian admixture intensified, with North and East Xinjiang populations showing more affinity with northeastern Asians and South Xinjiang populations showing more affinity with Central Asians. The genetic structure observed in the Historical Era of Xinjiang is similar to that in the Iron Age, demonstrating genetic continuity since the Iron Age with some additional genetic admixture with populations surrounding the Xinjiang region.

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Ancient Xinjiang mitogenomes reveal intense admixture with high genetic diversity

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