TY - JOUR
T1 - Anti-hyperlipidemic effect of methanol bark extract of Terminalia chebula in male albino Wistar rats
AU - Reddy, Murali Mohan
AU - Dhas Devavaram, Jackson
AU - Dhas, Jebasingh
AU - Adeghate, Ernest
AU - Starling Emerald, Bright
N1 - Publisher Copyright:
© 2015 Informa Healthcare USA, Inc. All rights reserved.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Context: Hyperlipidemia is known to be a major risk factor for the development of cardiovascular diseases (CVDs) which include atherosclerosis, coronary heart disease, and stroke. Although there are a large number of anti-hyperlipidemic drugs available, unfortunately, they all have side effects. Objective: Terminalia chebula Retz. (Combretaceae) is a plant used to treat cardiac disorders in the traditional Ayurveda medicine in India. The objective of this study was to assess the anti-hyperlipidemic properties of a methanol (MeOH) bark extract of T. chebula. Materials and methods: Acute toxicity studies were performed according to the Organisation for Economic Cooperation and Development (OECD) guideline no. 423 using various doses (5, 50, 300, and 2000 mg/kg) of T. chebula bark. Anti-hyperlipidemic effect of MeOH bark extract of T. chebula at doses of 200, 400, and 600 mg/kg and fasting glucose levels after treatment with MeOH bark extract of T. chebula at doses of 200, 400, and 600 mg/kg were analyzed using commercially available kits. Results: Acute toxicity studies did not show any morbidity and mortality at various doses. The MeOH extract of T. chebula bark at doses of 200, 400, and 600 mg/kg significantly lowered serum cholesterol and triglyceride levels. Moreover, the extract of T. chebula and the positive control atorvastatin-treated groups of animals showed a significant increase in the serum high-density lipoprotein (HDL) cholesterol levels in diet-induced hypercholesterolemic animals. Conclusion: The overall results confirm that the bark extract of T. chebula possesses significant anti-hyperlipidemic activity.
AB - Context: Hyperlipidemia is known to be a major risk factor for the development of cardiovascular diseases (CVDs) which include atherosclerosis, coronary heart disease, and stroke. Although there are a large number of anti-hyperlipidemic drugs available, unfortunately, they all have side effects. Objective: Terminalia chebula Retz. (Combretaceae) is a plant used to treat cardiac disorders in the traditional Ayurveda medicine in India. The objective of this study was to assess the anti-hyperlipidemic properties of a methanol (MeOH) bark extract of T. chebula. Materials and methods: Acute toxicity studies were performed according to the Organisation for Economic Cooperation and Development (OECD) guideline no. 423 using various doses (5, 50, 300, and 2000 mg/kg) of T. chebula bark. Anti-hyperlipidemic effect of MeOH bark extract of T. chebula at doses of 200, 400, and 600 mg/kg and fasting glucose levels after treatment with MeOH bark extract of T. chebula at doses of 200, 400, and 600 mg/kg were analyzed using commercially available kits. Results: Acute toxicity studies did not show any morbidity and mortality at various doses. The MeOH extract of T. chebula bark at doses of 200, 400, and 600 mg/kg significantly lowered serum cholesterol and triglyceride levels. Moreover, the extract of T. chebula and the positive control atorvastatin-treated groups of animals showed a significant increase in the serum high-density lipoprotein (HDL) cholesterol levels in diet-induced hypercholesterolemic animals. Conclusion: The overall results confirm that the bark extract of T. chebula possesses significant anti-hyperlipidemic activity.
KW - Acute toxicity study
KW - Anti-hyperlipidemic property
KW - MeOH bark extract
KW - Statins
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U2 - 10.3109/13880209.2014.962058
DO - 10.3109/13880209.2014.962058
M3 - Article
C2 - 25625850
AN - SCOPUS:84930804617
SN - 1388-0209
VL - 53
SP - 1133
EP - 1140
JO - Pharmaceutical Biology
JF - Pharmaceutical Biology
IS - 8
ER -