Anti-inflammatory cytokine response and clinical outcome in acute pancreatitis

Misho O. Simovic, Martin J.D. Bonham, Fikri M. Abu-Zidan, John A. Windsor

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)


Objective: To test the hypothesis that elevated interleukin (IL)-10 plasma concentration relative to IL-6 and IL-8 in patients with acute pancreatitis is associated with improved clinical outcome. Design: Case series. Setting: University hospital surgical and intensive care unit. Patients: Patients with mild (n = 18) and severe (n = 14) acute pancreatitis were recruited within 12 hrs of admission and studied for 5 days. Interventions: None. Measurements and Main Results: The plasma concentration of IL-10 was significantly elevated in patients with severe pancreatitis during the 5 days and especially so in those who died compared with survivors on day 5 (p <.03). The ratio of IL-10/IL-6 was decreased in patients with severe pancreatitis on day 5 (p < .01). There was a significant decrease in the ratio of IL10/IL-8, but not of IL-10/IL-6, during the first 5 days (p < .014). Conclusions: The findings are consistent with the hypothesis that an increase in plasma IL-10 relative to IL-6 or IL-8 is associated with improved clinical outcome.

Original languageEnglish
Pages (from-to)2662-2665
Number of pages4
JournalCritical Care Medicine
Issue number12
Publication statusPublished - 1999
Externally publishedYes


  • Acute pancreatitis
  • Cytokines
  • Homeostasis
  • Inflammation
  • Interleukin-10
  • Interleukin-6
  • Interleukin-8
  • Multiple organ failure
  • Septicemia

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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