Anti-tumor effects of vitamin B2, B6 and B9 in promonocytic lymphoma cells

Kathleen Mikkelsen, Monica D. Prakash, Nyanbol Kuol, Kulmira Nurgali, Lily Stojanovska, Vasso Apostolopoulos

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Chronic inflammation can lead to tumour initiation and progression. Vitamin B complex has the ability to regulate the immune response and, therefore, inflammation but many of the mechanistic and molecular processes involved in this regulation are still not fully understood. This study sought to determine some of these processes by studying the effects of vitamin B2 (riboflavin) B6 (pyridoxine) and B9 (folic acid) on un-differentiated pro-monocytic lymphoma cells in regard to their ability to alter the proliferation, migration, apoptosis, cytokines and expression levels of programmed death ligand 1. We show that vitamin B2, B6 and B9, on pro-monocytic lymphoma cells exerted an anti-tumorigenic effect. This data could form the basis for future studies in using vitamin B supplementation to reduce cancer cell growth in vivo.

Original languageEnglish
Article number3763
JournalInternational journal of molecular sciences
Volume20
Issue number15
DOIs
Publication statusPublished - Aug 1 2019

Keywords

  • Folate
  • Pro-monocytes
  • Pyridoxine
  • Riboflavin
  • U937 cell line
  • Vitamin B complex
  • Vitamin B2
  • Vitamin B6
  • Vitamin B9

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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