@article{7bb71a01d0fa4da29cd442d47c7cd8ce,
title = "Anti-tumor effects of vitamin B2, B6 and B9 in promonocytic lymphoma cells",
abstract = "Chronic inflammation can lead to tumour initiation and progression. Vitamin B complex has the ability to regulate the immune response and, therefore, inflammation but many of the mechanistic and molecular processes involved in this regulation are still not fully understood. This study sought to determine some of these processes by studying the effects of vitamin B2 (riboflavin) B6 (pyridoxine) and B9 (folic acid) on un-differentiated pro-monocytic lymphoma cells in regard to their ability to alter the proliferation, migration, apoptosis, cytokines and expression levels of programmed death ligand 1. We show that vitamin B2, B6 and B9, on pro-monocytic lymphoma cells exerted an anti-tumorigenic effect. This data could form the basis for future studies in using vitamin B supplementation to reduce cancer cell growth in vivo.",
keywords = "Folate, Pro-monocytes, Pyridoxine, Riboflavin, U937 cell line, Vitamin B complex, Vitamin B2, Vitamin B6, Vitamin B9",
author = "Kathleen Mikkelsen and Prakash, {Monica D.} and Nyanbol Kuol and Kulmira Nurgali and Lily Stojanovska and Vasso Apostolopoulos",
note = "Funding Information: V.A. and L.S. were supported by the Rebecca L Cooper Medical Research Foundation, Australia, and supported, in part, this research project. K.M. was supported by the Victoria University postgraduate scholarship and the Vice-Chancellors top-up scholarship and N.K. was supported by the Victoria University postgraduate scholarship. V.A. would like to thank The Thelma and Paul Constantinou Foundation, whose generous philanthropic support made possible the preparation of this paper. All authors would like to thank the Immunology Program of the Centre for Chronic Disease and Mechanisms and Interventions in Health and Disease program of the Institute for Health and Sport, Victoria University, for their support. Funding Information: Acknowledgments: K.M. was supported by the Victoria University postgraduate scholarship and the Vice-Chancellors top-up scholarship and N.K. was supported by the Victoria University postgraduate scholarship. V.A. would like to thank The Thelma and Paul Constantinou Foundation, whose generous philanthropic support made possible the preparation of this paper. All authors would like to thank the Immunology Program of the Centre for Chronic Disease and Mechanisms and Interventions in Health and Disease program of the Institute for Health and Sport, Victoria University, for their support. Funding Information: Funding: V.A. and L.S. were supported by the Rebecca L Cooper Medical Research Foundation, Australia, and supported, in part, this research project. Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2019",
month = aug,
day = "1",
doi = "10.3390/ijms20153763",
language = "English",
volume = "20",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "15",
}