Abstract
In the present study, effect of hydro-alcoholic extract of Tribulus terrestris (TT-75 & 150 mg/kg/day for 30 days) on lipid peroxidation product, malonaldialdehyde (MDA) and endogenous antioxidant enzyme, superoxide dismutase (SOD) was evaluated against isoprenaline (ISO) induced oxidative stress in rat hearts. Isoprenaline administration resulted in marked increase in MDA with a concomitant decline in myocardial SOD activity. However, TT treatment significantly protected it against oxidative stress as it restored myocardial SOD activity and decreased MDA content. The protective effect of Tribulus terrestris against oxidative stress might be due to its flavonoid and saponin constituents, which confer its free radical scavenging and anti-peroxidative activity.
Original language | English |
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Pages (from-to) | 136-140 |
Number of pages | 5 |
Journal | Indian Drugs |
Volume | 43 |
Issue number | 2 |
Publication status | Published - Feb 2006 |
Externally published | Yes |
Keywords
- Malonaldialdehyde
- Oxygen free radicals
- Superoxide dismutase
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
- Drug Discovery