Antilipidperoxidative and free radical scavenging activity of Tribulus Terrestris

S. K. Ojha, M. Nandave, S. Kumari, D. S. Arya

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


In the present study, effect of hydro-alcoholic extract of Tribulus terrestris (TT-75 & 150 mg/kg/day for 30 days) on lipid peroxidation product, malonaldialdehyde (MDA) and endogenous antioxidant enzyme, superoxide dismutase (SOD) was evaluated against isoprenaline (ISO) induced oxidative stress in rat hearts. Isoprenaline administration resulted in marked increase in MDA with a concomitant decline in myocardial SOD activity. However, TT treatment significantly protected it against oxidative stress as it restored myocardial SOD activity and decreased MDA content. The protective effect of Tribulus terrestris against oxidative stress might be due to its flavonoid and saponin constituents, which confer its free radical scavenging and anti-peroxidative activity.

Original languageEnglish
Pages (from-to)136-140
Number of pages5
JournalIndian Drugs
Issue number2
Publication statusPublished - Feb 2006
Externally publishedYes


  • Malonaldialdehyde
  • Oxygen free radicals
  • Superoxide dismutase

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery


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