Two series of novel 3-cyano-2-(2,3,4,6-tetra-O-acetyl-β-D- glucopyranosyloxo) pyridines and 3-cyano-2-(2,3,5-tri-O-acetyl-β-D- ribofuranosyloxy)-4-trifluromethyl-6-phenyl pyridine were synthesized using efficient microwave methods. The targeted compounds were obtained in high yields by reacting 2-(1H)-pyridone or its salt with activated sugars using SiO 2 under solvent-free conditions. Ammonolysis of the resulted acetylated nucleosides produced 3-cyano-2-(β-D-glucopyranosyloxo)-pyridines and 3-cyano-2-(β-D-ribofuranosyloxy)-4-trifluoromethyl-6-phenyl pyridine. These new products were fully characterized using 1D and 2D NMR. These compounds were screened for their antibacterial activities against G+ and G- bacteria and some found to exhibit better antibacterial activities than the control drug.
|Number of pages||17|
|Journal||Nucleosides, Nucleotides and Nucleic Acids|
|Publication status||Published - Sept 2 2013|
- green synthesis
- solvent-free conditions
ASJC Scopus subject areas
- Molecular Medicine