Application of nanomagnetic particles in hyperthermia cancer treatment

This research focuses on developing uniform particles with a Curie temperature that is similar to the therapeutic one for the purpose of cancer treatment. Such particles will self-regulate the temperature of the tumor during magnetic hyperthermia (MH), thus avoiding the use of temperature controls. MH is based on a defined transfer of power onto magnetic nanoparticles in an alternate magnetic field that is determined by the frequency, magnetic field's strength, materials and the size of the particles, which result in localized generation of heat. This heat will either destroy the tumor cells directly or results in a synergic reinforcement of radiation efficacy, depending on the equilibrium temperature set in the tumor tissue. MH involves the local deposition of tumor cell specific magnetic nanoparticles and an external alternating current magnetic field applicator system. Nanoferrite particles can be easily applied interstitially for minimum invasive application. In this study more uniform nanoparticles have been manufactured and they were tested for their Curie temperature for self-regulated MH. Materials which have been investigated for such procedure are Gd-Zn ferrite, MnZnFe₂O ₄ and La_3/4Sr_1/4MnO₃ and many others. Finally, the concept of discrete magnetic heating is addressed.