Are the strokes in moyamoya syndrome associated with Down syndrome due to protein C deficiency?

A. Gururaj, D. Hardy, L. I. Al-Gazali, L. Sztriha, A. Roos, M. Nork

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Moyamoya syndrome has occasionally been seen in association with Down syndrome. We report a child with moyamoya syndrome and Down syndrome who was admitted with repeated episodes of strokes; his magnetic resonance imaging and magnetic resonance angiography findings confirmed the presence of occlusive cerebrovascular disease with basal collateral vessels. His protein C levels were significantly decreased during the stroke. Complete clinical recovery was seen during follow-up. This raises the possibility of a link between protein C deficiency and Down syndrome with moyamoya syndrome.

Original languageEnglish
Pages (from-to)719-722
Number of pages4
JournalBrain and Development
Volume24
Issue number7
DOIs
Publication statusPublished - Oct 2002

Keywords

  • Down syndrome
  • Magnetic resonance angiography
  • Moyamoya disease
  • Moyamoya syndrome
  • Protein C

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

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