TY - JOUR
T1 - Assessment of chloroquine resistance of Plasmodium falciparum in children of Wad Medani (central Sudan)
AU - Ibrahim, Adil M.
AU - Ali, Fath El Rahman A.
AU - Ali, Mohi Eldin M.
PY - 1992/8
Y1 - 1992/8
N2 - Summary: The study reports on chloroquine resistance of Plasmodium falciparum among Sudanese children (6 month to 16 years) living at Wad Medani, Central Sudan. AH RI-III levels of resistant response were confirmed, while in vitro sensitivity test indicated that 25 per cent of P. falciparum isolates examined had exhibited maturation of schizonts at CQ level ≥1.6 pmol/μl blood. CQ was sufficiently retained for 7 days after drug administration whereas an average peak level of CQ in blood (348 ng/ml) was recorded on day 1. Patients were successfully treated by an age-measured dose of parenteral quinine (10 mg/kg).
AB - Summary: The study reports on chloroquine resistance of Plasmodium falciparum among Sudanese children (6 month to 16 years) living at Wad Medani, Central Sudan. AH RI-III levels of resistant response were confirmed, while in vitro sensitivity test indicated that 25 per cent of P. falciparum isolates examined had exhibited maturation of schizonts at CQ level ≥1.6 pmol/μl blood. CQ was sufficiently retained for 7 days after drug administration whereas an average peak level of CQ in blood (348 ng/ml) was recorded on day 1. Patients were successfully treated by an age-measured dose of parenteral quinine (10 mg/kg).
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U2 - 10.1093/tropej/38.4.162
DO - 10.1093/tropej/38.4.162
M3 - Article
C2 - 1527810
AN - SCOPUS:0026666007
SN - 0142-6338
VL - 38
SP - 162
EP - 166
JO - Journal of Tropical Pediatrics
JF - Journal of Tropical Pediatrics
IS - 4
ER -